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Enfermedad hepática esteatótica asociada a la disfunción metabólica y la progresión longitudinal de la fibrilación
Yali Niu1, Tianrun Wang2, Xiaocan Jia1
1Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Nutrition, metabolism, and cardiovascular diseases : NMCD
|August 30, 2025
Resumen
La enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD) aumenta el riesgo de progresión de la fibrilación auricular (FA). El grosor de la íntima media carotídea (cIMT) interviene significativamente en esta asociación, lo que pone de relieve la necesidad de monitorear la aterosclerosis en pacientes con MASLD.
Área de la Ciencia:
- Cardiología
- Hepatología
- Enfermedades metabólicas
Sus antecedentes:
- La fibrilación auricular (FA) a menudo coexiste con complicaciones cardiovasculares como el infarto de miocardio y el accidente cerebrovascular.
- La enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD) es un factor poco reconocido en el desarrollo y la mortalidad de la FA.
- El grosor de la carótida íntima-media (cIMT) es un marcador de la aterosclerosis y puede mediar el vínculo entre MASLD y AF.
Objetivo del estudio:
- Investigar el impacto del MASLD en la progresión longitudinal de la FA.
- Determinar el papel mediador de cIMT en la asociación entre la progresión, las complicaciones y la mortalidad de MASLD y FA.
Principales métodos:
- Análisis multestatal de 350,745 participantes durante una mediana de 13,67 años.
- Análisis de la mediación contrafactual para cuantificar el efecto mediador de cIMT.
- Examinó las transiciones de la salud a la FA, las complicaciones relacionadas con la FA y la muerte.
Principales resultados:
- Los pacientes con MASLD mostraron un riesgo 1,52 veces mayor de transición de salud a FA en comparación con los individuos sin MASLD.
- cIMT medió el 16,51% de la asociación entre MASLD y FA, el 18,06% para las complicaciones de la FA y el 15,14% para la mortalidad.
- Se observaron asociaciones significativas de MASLD con la progresión de la FA, las complicaciones posteriores y la mortalidad general.
Conclusiones:
- MASLD aumenta significativamente el riesgo de avance longitudinal de la FA.
- cIMT actúa como un mediador clave en la relación MASLD-AF.
- El manejo de MASLD y el monitoreo de la aterosclerosis son cruciales para prevenir la progresión de la FA.
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