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La ingesta dietética de vitamina E está asociada con una menor mortalidad entre las personas con enfermedad hepática
Yajie Peng1, Wanhong Wu2, Lin Chen3
1Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China.
Nutrition research (New York, N.Y.)
|August 31, 2025
Resumen
Una mayor ingesta dietética de vitamina E está relacionada con una reducción de la mortalidad en pacientes con enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD). Esto sugiere que la vitamina E puede ser una intervención dietética beneficiosa para los pacientes con MASLD.
Área de la Ciencia:
- Hepatología
- Ciencias de la nutrición
- Salud pública
Sus antecedentes:
- La enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD, por sus siglas en inglés) es un problema de salud mundial cada vez mayor.
- Las modificaciones dietéticas son cruciales para el manejo de MASLD.
- El impacto específico de la vitamina E en la dieta sobre la mortalidad de los pacientes con MASLD requiere más aclaraciones.
Objetivo del estudio:
- Investigar la asociación entre la ingesta dietética de vitamina E y el riesgo de mortalidad en pacientes diagnosticados con MASLD.
- Determinar si el aumento del consumo de vitamina E se correlaciona con mejores resultados de supervivencia en esta población.
Principales métodos:
- Se utilizaron datos de la Encuesta Nacional de Examen de Salud y Nutrición (NHANES) (1999-2018) y el Índice Nacional de Muertes (NDI).
- Se incluyeron 7883 pacientes con MASLD, evaluando la ingesta dietética de vitamina E utilizando métodos estandarizados del USDA.
- Empleado curvas de Kaplan-Meier, modelos de regresión de Cox, y ajustado para múltiples factores de confusión.
Principales resultados:
- Una mayor ingesta dietética de vitamina E se asoció significativamente con un riesgo reducido de mortalidad por cualquier causa.
- El aumento del consumo de vitamina E se correlacionó con un menor riesgo de mortalidad por enfermedades cardiovasculares (ECV) en los pacientes con MASLD.
- Los efectos protectores fueron más pronunciados en individuos no sedentarios y en aquellos con niveles elevados de bilirrubina total o fibrosis hepática.
Conclusiones:
- La ingesta dietética de vitamina E demuestra una relación inversa significativa con la mortalidad en los pacientes con MASLD.
- El aumento de la vitamina E en la dieta puede representar una estrategia preventiva prometedora para mejorar los resultados en MASLD.
- Se justifica una mayor investigación sobre la vitamina E como una intervención terapéutica para el MASLD.
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