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Síndrome de piernas inquietas y su asociación con el grosor del tejido adiposo de las extremidades inferiores: una
Elif Sarica Darol1, Dilcan Kotan2
1Sakarya University, Training and Research Hospital, Neurology Clinic, Sakarya, Türkiye.
Arquivos de neuro-psiquiatria
|August 31, 2025
Resumen
El grosor del tejido adiposo subcutáneo de las extremidades inferiores puede desempeñar un papel en la fisiopatología del síndrome de piernas inquietas (RLS). La reducción del grosor del tejido adiposo de la pantorrilla se asoció significativamente con el SLR, independientemente del índice de masa corporal.
Área de la Ciencia:
- Neurología
- Trastornos del metabolismo
- Análisis de la composición corporal
Sus antecedentes:
- El síndrome de piernas inquietas (RLS) es un trastorno neurológico con factores de riesgo conocidos que incluyen el género femenino y la obesidad.
- La relación entre RLS y la composición corporal, específicamente el grosor del tejido adiposo subcutáneo (ATT), sigue siendo poco explorada, particularmente independiente del índice de masa corporal (IMC).
Objetivo del estudio:
- Investigar la correlación entre el grosor del tejido adiposo subcutáneo de las extremidades inferiores (ATT) y el síndrome de piernas inquietas (RLS).
- Determinar si la ATT está asociada con el RLS independientemente del IMC.
Principales métodos:
- Un estudio de caso-control en el que participaron 212 pacientes con SLR y 92 controles.
- El grosor del tejido adiposo (ATT) se midió utilizando pinzas en las regiones de la pantorrilla y la rodilla.
- El análisis estadístico incluyó regresión logística múltiple para evaluar la asociación entre ATT y RLS, controlando otros factores.
Principales resultados:
- La ATT media fue significativamente más baja en los pacientes con ESR en comparación con los controles (p < 0,0005).
- Una disminución de la ATT media de la pantorrilla se asoció con un aumento de la probabilidad de RLS (OR=1,107 por unidad de disminución).
- Factores como la edad, la ferritina y los niveles de vitamina D también se asociaron de forma independiente con la probabilidad de RLS.
Conclusiones:
- El grosor del tejido adiposo subcutáneo de las extremidades inferiores, particularmente en la región media de la pantorrilla, puede ser un factor significativo en la fisiopatología del SRA.
- Esta asociación parece ser independiente del IMC general, lo que sugiere un papel localizado para el tejido adiposo.
- Se necesita más investigación para dilucidar los mecanismos subyacentes a la relación entre la ATT de las piernas y el SRA.
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