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Dermatitis por recuerdo de radiación después de la administración de capivasertib
Yuhao Shi1, Ian W Tattersall2, Boris Kobrinsky3
1Department of Radiation Oncology, New York University Grossman School of Medicine, New York, New York.
Practical radiation oncology
|August 31, 2025
Resumen
Se produjo dermatitis por retiro de radiación en una paciente tratada con capivasertib, un inhibidor de la vía PI3K/ Akt, para cáncer de mama metastásico. Este raro efecto adverso pone de relieve la necesidad de precaución al usar capivasertib en pacientes con radioterapia previa.
Área de la Ciencia:
- En el campo de la oncología
- Farmacología
Sus antecedentes:
- La dermatitis por retiro de radiación es un efecto adverso raro.
- Capivasertib es un inhibidor de la vía PI3K/ Akt aprobado para el cáncer de mama.
- Se desconoce su seguridad con la radiación paliativa.
Objetivo del estudio:
- Para reportar un caso de dermatitis por radiación.
- Para analizar la seguridad de capivasertib en pacientes con radiación previa.
Principales métodos:
- Informe de caso de una paciente con cáncer de mama metastásico.
- El paciente recibió capivasertib después de una radiación previa en la extremidad inferior.
Principales resultados:
- El paciente desarrolló dermatitis por radiación.
- El tratamiento incluyó corticosteroides, antibióticos y cambio a alpelisib.
Conclusiones:
- Capivasertib puede desencadenar dermatitis por retiro de radiación.
- Se recomienda precaución al usar capivasertib en pacientes con antecedentes de radiación.
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