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Se produjo dermatitis por retiro de radiación en una paciente tratada con capivasertib, un inhibidor de la vía PI3K/ Akt, para cáncer de mama metastásico. Este raro efecto adverso pone de relieve la necesidad de precaución al usar capivasertib en pacientes con radioterapia previa.

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Área de la Ciencia:

  • En el campo de la oncología
  • Farmacología

Sus antecedentes:

  • La dermatitis por retiro de radiación es un efecto adverso raro.
  • Capivasertib es un inhibidor de la vía PI3K/ Akt aprobado para el cáncer de mama.
  • Se desconoce su seguridad con la radiación paliativa.

Objetivo del estudio:

  • Para reportar un caso de dermatitis por radiación.
  • Para analizar la seguridad de capivasertib en pacientes con radiación previa.

Principales métodos:

  • Informe de caso de una paciente con cáncer de mama metastásico.
  • El paciente recibió capivasertib después de una radiación previa en la extremidad inferior.

Principales resultados:

  • El paciente desarrolló dermatitis por radiación.
  • El tratamiento incluyó corticosteroides, antibióticos y cambio a alpelisib.

Conclusiones:

  • Capivasertib puede desencadenar dermatitis por retiro de radiación.
  • Se recomienda precaución al usar capivasertib en pacientes con antecedentes de radiación.