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Mejorar la biodisponibilidad del cannabidiol: desarrollo y evaluación de una formulación de polvo de cannabidiol
Hiroki Aoyama1, Tatsuya Ogawa1, Hitomi Ozawa-Umeta1
1Therabiopharma Inc.
Journal of nutritional science and vitaminology
|August 31, 2025
Resumen
Los investigadores desarrollaron un polvo de cannabidiol (CBD) amorfo para superar la baja biodisponibilidad. Esta formulación mejorada aumenta significativamente la absorción de CBD, allanando el camino para un uso mejorado en alimentos y suplementos.
Área de la Ciencia:
- Farmacología
- Ciencias de los materiales
Sus antecedentes:
- El cannabidiol (CBD) posee numerosas propiedades beneficiosas, incluidos los efectos antioxidantes, antiinflamatorios y ansiolíticos.
- Las aplicaciones clínicas del CBD se ven obstaculizadas por su baja biodisponibilidad oral inherente.
- El desarrollo de sistemas avanzados de administración es crucial para mejorar el potencial terapéutico del CDB.
Objetivo del estudio:
- Desarrollar una formulación en polvo de cannabidiol (CBD) amorfo con mejor biodisponibilidad.
- Evaluar el perfil farmacocinético de la formulación amorfa de CBD en ratas.
- Evaluar el impacto de los diferentes polímeros en la absorción del CDB.
Principales métodos:
- Se preparó un polvo de CBD amorfo utilizando un método de desplazamiento de disolventes de grado alimenticio.
- Se realizaron estudios farmacocinéticos en ratas Sprague-Dawley, comparando las formulaciones amorfas (F3 con PVP, F4 con HPMC) con el aislado de CBD cristalino.
- Se analizaron los parámetros farmacocinéticos clave, incluidos Cmax, AUC0- 6h y Tmax.
Principales resultados:
- Las formulaciones amorfas de CBD mostraron una biodisponibilidad significativamente mejorada en comparación con el CBD cristalino.
- La Cmax aumentó 3,9 veces (F3) y 3,0 veces (F4).
- Los valores AUC0- 6h fueron 5,3 veces (F3) y 5,2 veces (F4) más altos, con una Tmax significativamente reducida.
Conclusiones:
- La formulación de polvo de CBD amorfo desarrollada demuestra una biodisponibilidad superior.
- El uso de polímeros como PVP y HPMC mejora efectivamente la absorción de CBD.
- Esta formulación es prometedora para aumentar la eficacia del CBD en aplicaciones de alimentos y suplementos.
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