Video Experimental Relacionado
Updated: Sep 9, 2025
06:50
Extraction and Analysis of Taiwanese Green Propolis
Published on: January 7, 2019
8.6K
El propóleo verde brasileño regula la termogénesis a través de dos vías distintas
Takuma Hyodo1, Nobuaki Okumura1, Takanori Tsuda2
1Institute for Bee Products and Health Science, Yamada Bee Company Inc.
Journal of nutritional science and vitaminology
|August 31, 2025
Resumen
El propóleo verde brasileño (BGP) activa dos vías distintas de termogénesis. Culifolin, un componente de BGP, estimula la termogénesis del tejido adiposo marrón (BAT) a través de TRPV1, mientras que Artepillin C promueve la formación de adipocitos beige, aumentando el gasto de energía.
Área de la Ciencia:
- Investigación metabólica
- Biología del tejido adiposo
- Química de los productos naturales
Sus antecedentes:
- El propóleo verde brasileño (BGP) acelera el metabolismo e induce los adipocitos beige.
- Artepillin C (ArtC), un compuesto BGP clave, promueve la formación de adipocitos beige y la termogénesis en el tejido adiposo blanco.
- Los mecanismos precisos de los efectos de la BGP en la formación de adipocitos beige y el metabolismo energético requieren más aclaración.
Objetivo del estudio:
- Investigar los efectos del BGP en la formación de adipocitos beige y la termogénesis.
- Identificar los componentes específicos del BGP responsables de estos efectos.
- Para aclarar las vías moleculares involucradas en la termogénesis mediada por BGP.
Principales métodos:
- Ensayos de cultivo y diferenciación celular in vitro.
- Estudios in vivo que incluyan pruebas de componentes y mediciones de termogénesis.
- Ensayos de afluencia de calcio y estudios inhibidores dirigidos al canal TRPV1.
Principales resultados:
- Se confirmó que la artepilina C (ArtC) es un componente primario de la BGP que impulsa la formación de adipocitos beige.
- La termogénesis inducida por BGP en el tejido adiposo marrón interescapular (iBAT) no fue mediada por ArtC.
- Culifolin, otro derivado de BGP, fue identificado como un activador de la termogénesis iBAT a través de la vía del sistema nervioso simpático TRPV1, aumentando la temperatura iBAT de manera similar a BGP.
Conclusiones:
- BGP activa de manera única dos vías de termogénesis separadas: la formación de adipocitos beige (a través de ArtC) y la termogénesis de adipocitos marrones (a través de culifolina).
- La activación de la señalización TRPV1 en iBAT por parte de Culifolin contribuye significativamente a los efectos termogénicos de BGP.
- BGP aumenta el gasto de energía a través de mecanismos distintos que involucran tanto el tejido adiposo marrón como el beige.
Videos de Conceptos Relacionados
01:19Regulation of Metabolism
9.8K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.8K
01:26Thermoregulation
1.2K
The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...
1.2K
01:19Energy Balance
540
The human body gets energy from the three macronutrients: carbohydrates, proteins, and fats. Energy is released when the chemical bonds in the organic compounds present in the food are broken down. The energy content of food is measured in kilocalories (kcal), defined as the amount of heat required to raise the temperature of one kilogram of water by one degree Celsius. This value is determined by measuring the temperature change of the water surrounding a calorimeter after the complete...
540
01:30Regulation of Food Intake
350
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
350
01:16Hormones Regulating Blood Glucose
4.0K
Insulin is released by beta cells of the pancreas when blood glucose levels are high. It facilitates glucose absorption and utilization in insulin-dependent cells with insulin receptors on their plasma membranes. Insulin promotes glucose uptake by increasing the number of glucose transport proteins in the cell membrane, allowing glucose to enter the cell. As a result, glucose utilization and ATP production are enhanced.
In addition to accelerating glucose uptake and utilization, insulin has...
In addition to accelerating glucose uptake and utilization, insulin has...
4.0K
01:43Thermosensation
31.8K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
31.8K