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El propóleo verde brasileño regula la termogénesis a través de dos vías distintas

Takuma Hyodo1, Nobuaki Okumura1, Takanori Tsuda2

  • 1Institute for Bee Products and Health Science, Yamada Bee Company Inc.

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Resumen

El propóleo verde brasileño (BGP) activa dos vías distintas de termogénesis. Culifolin, un componente de BGP, estimula la termogénesis del tejido adiposo marrón (BAT) a través de TRPV1, mientras que Artepillin C promueve la formación de adipocitos beige, aumentando el gasto de energía.

Palabras clave:
Própolis verde brasileñoAdipocito de color beigeadipocito marrónCulifolina y sus derivadosTermogénesispotencial de recepción transitorio del vanilloide 1Proteína de desacoplamiento 1

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Área de la Ciencia:

  • Investigación metabólica
  • Biología del tejido adiposo
  • Química de los productos naturales

Sus antecedentes:

  • El propóleo verde brasileño (BGP) acelera el metabolismo e induce los adipocitos beige.
  • Artepillin C (ArtC), un compuesto BGP clave, promueve la formación de adipocitos beige y la termogénesis en el tejido adiposo blanco.
  • Los mecanismos precisos de los efectos de la BGP en la formación de adipocitos beige y el metabolismo energético requieren más aclaración.

Objetivo del estudio:

  • Investigar los efectos del BGP en la formación de adipocitos beige y la termogénesis.
  • Identificar los componentes específicos del BGP responsables de estos efectos.
  • Para aclarar las vías moleculares involucradas en la termogénesis mediada por BGP.

Principales métodos:

  • Ensayos de cultivo y diferenciación celular in vitro.
  • Estudios in vivo que incluyan pruebas de componentes y mediciones de termogénesis.
  • Ensayos de afluencia de calcio y estudios inhibidores dirigidos al canal TRPV1.

Principales resultados:

  • Se confirmó que la artepilina C (ArtC) es un componente primario de la BGP que impulsa la formación de adipocitos beige.
  • La termogénesis inducida por BGP en el tejido adiposo marrón interescapular (iBAT) no fue mediada por ArtC.
  • Culifolin, otro derivado de BGP, fue identificado como un activador de la termogénesis iBAT a través de la vía del sistema nervioso simpático TRPV1, aumentando la temperatura iBAT de manera similar a BGP.

Conclusiones:

  • BGP activa de manera única dos vías de termogénesis separadas: la formación de adipocitos beige (a través de ArtC) y la termogénesis de adipocitos marrones (a través de culifolina).
  • La activación de la señalización TRPV1 en iBAT por parte de Culifolin contribuye significativamente a los efectos termogénicos de BGP.
  • BGP aumenta el gasto de energía a través de mecanismos distintos que involucran tanto el tejido adiposo marrón como el beige.