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¿Es necesario un aclaramiento dental antes del tratamiento antiresortivo en pacientes pediátricos?
Timothy W Neal1, Sayyed Mohseni1, Victoria Ratcliffe1
1Department of Surgery, Division of Oral and Maxillofacial Surgery, UT Southwestern/Parkland Memorial Hospital, Dallas, TX, USA.
Oral surgery, oral medicine, oral pathology and oral radiology
|August 31, 2025
Resumen
Los pacientes pediátricos que recibieron un aclaramiento dental antes de la terapia antiresortiva no mostraron un aumento en el riesgo de osteonecrosis de las mandíbulas relacionada con la medicación (MRONJ). El aclaramiento dental se asoció con una mejor atención de seguimiento.
Área de la Ciencia:
- Odontología pediátrica
- Medicina Oral
- Farmacología
Sus antecedentes:
- La osteonecrosis de las mandíbulas relacionada con la medicación (MRONJ) es una complicación potencial del tratamiento antiresortivo.
- La función del aclaramiento dental previo al tratamiento en pacientes pediátricos que reciben agentes antiresortivos requiere investigación.
Objetivo del estudio:
- Comparar la incidencia de MRONJ en pacientes pediátricos con y sin aclaramiento dental previo al tratamiento.
- Evaluar el impacto del aclaramiento dental en la frecuencia del seguimiento dental posterior al tratamiento.
Principales métodos:
- Estudio retrospectivo de pacientes pediátricos (< 18 años) tratados con antiresortivos (2010-2024).
- Comparación de la incidencia de MRONJ y la frecuencia de las visitas dentales entre los grupos con y sin aclaramiento dental previo al tratamiento.
Principales resultados:
- No se observaron casos de MRONJ ni en el grupo con aclaramiento (n=88) ni en el grupo sin aclaramiento (n=48).
- El grupo con aclaramiento mostró visitas dentales anuales promedio significativamente más altas después de la terapia (1.21) en comparación con el grupo sin aclaramiento (0.55) (P = .0002).
Conclusiones:
- El aclaramiento dental previo al tratamiento no parece aumentar el riesgo de MRONJ en pacientes pediátricos en tratamiento antirresortivo.
- El aclaramiento dental se asocia con un seguimiento dental de rutina sostenido en esta población.
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