Video Experimental Relacionado
Updated: May 3, 2026
12:04
Intra-Operative Behavioral Tasks in Awake Humans Undergoing Deep Brain Stimulation Surgery
Published on: January 6, 2011
13.1K
Craniotomía en estado de vigilia versus vigilia para el glioblastoma elocuente: una revisión sistemática y un
Susan I Honeyman1, Alexandros Boukas2, Melika Akhbari2
1Department of Neurosurgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. susan.honeyman@ouh.nhs.uk.
Neurosurgical review
|August 31, 2025
Resumen
La craneotomía despierta (AC) mejora el grado de resección y la supervivencia de los pacientes con glioblastoma (GB) en lugares elocuentes. Este método también reduce el riesgo de déficits neurológicos en comparación con la anestesia general.
Área de la Ciencia:
- Neurocirugía
- En el campo de la oncología
- Anestesiología
Sus antecedentes:
- La craneotomía despierta (CA) ayuda a preservar la función neurológica a través del mapeo intraoperatorio.
- La AC está relacionada con un mayor grado de resección (EOR) y menos déficits en pacientes con glioma.
- Existen pruebas limitadas de la utilidad de AC en el glioblastoma (GB) en comparación con los tumores de bajo grado.
Objetivo del estudio:
- Evaluar la seguridad y eficacia de la AC frente a la anestesia general (GA) para la resección de GB.
- Para comparar los resultados, incluida la EOR, los déficits neurológicos y las tasas de supervivencia.
Principales métodos:
- Revisión sistemática y metanálisis de los estudios originales.
- Incluidos los pacientes mayores de 18 años con grado histopatológico 4 GB en localizaciones elocuentes.
- Buscado en Medline, Embase y Pubmed hasta el 30 de junio de 2025.
Principales resultados:
- AC logró un mayor EOR (7,55%) y un aumento no significativo en las tasas totales de resección bruta.
- Significativamente menor riesgo de déficits neurológicos postoperatorios con AC (OR=0,55).
- Aumento significativo de la supervivencia global con AC (HR=7,99), pero no hay diferencia en la supervivencia libre de progresión.
Conclusiones:
- AC para GB ubicado elocuentemente está relacionado con una mejor EOR, supervivencia y complicaciones neurológicas reducidas.
- Se debe considerar la AC para la resección elocuente de GB cuando sea factible.
- AC ofrece un enfoque más seguro y eficaz para cirugías específicas de glioblastoma.
Más Videos Relacionados
Videos de Conceptos Relacionados
02:07Blind Procedures
10.8K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.8K
01:24Sleep-Wake Cycles
3.0K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
3.0K
01:11Understanding Sleep
1.7K
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
1.7K
01:07Narcolepsy
891
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
891
01:18Nightmares and Night Terrors
1.0K
Nightmares and night terrors represent two distinct types of sleep disturbances that differ in timing, characteristics, and the sleeper's recall of the event. Nightmares are vivid, disturbing dreams that usually awaken the sleeper from REM sleep, a stage of sleep where brain activity is high, and dreams are most frequent. Upon awakening, individuals often have detailed recollections of their nightmares, which can include themes of threats to survival, security, or self-esteem.
Nightmares...
Nightmares...
1.0K
01:24Substance Use Disorders Affecting Sleep
610
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
610