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Updated: May 6, 2026

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Optimización de la estabilidad coloidal y la viscosidad de anticuerpos multispecíficos en la interfaz de

Vanessa Siegmund1, Daniel Klewinghaus1, Jonas Teroerde1

  • 1Early Protein Supply & Characterization, Merck Healthcare KGaA, Darmstadt, Germany.

mAbs
|September 1, 2025
PubMed
Resumen

La optimización de anticuerpos multispecíficos implica abordar desafíos como la agregación y la viscosidad. La alineación de los puntos isoeléctricos del dominio (PI) mejoró la estabilidad coloidal y la viscosidad, mejorando la capacidad de desarrollo de anticuerpos.

Palabras clave:
Ingeniería de anticuerposEstabilidad coloidalformulacionesDesarrollo en siliciopunto isoeléctricoanticuerpos multiespecíficosviscosidad

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