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Enfermedad renal cardiovascular metabólica: una nueva nomenclatura
Paolo Pozzilli1,2, Maria Vittoria Messina1, Michael Roden3,4,5
1Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Diabetes/metabolism research and reviews
|September 1, 2025
Resumen
La enfermedad renal cardiovascular metabólica (Met-CVRD) se propone para definir mejor el síndrome, destacando la disfunción metabólica como el factor clave. La identificación temprana y la intervención con terapias como los agonistas de GLP-1 y los inhibidores de SGLT2 son cruciales para prevenir la progresión de la enfermedad.
Área de la Ciencia:
- Cardiología
- Nefrología
- Enfermedades metabólicas
Sus antecedentes:
- La enfermedad renal cardiovascular (ERC) tradicionalmente describe las condiciones coexistentes.
- La terminología existente pasa por alto el papel causal primario de las anomalías metabólicas.
Objetivo del estudio:
- Introducir el término Enfermedad renal cardiovascular metabólica (Met-CVRD) para enfatizar la disfunción metabólica como la patogénesis principal.
- Abogar por la identificación temprana y las estrategias de intervención para Met-CVRD.
Principales métodos:
- Revisión de la comprensión actual de las interrelaciones entre la DRCV y la diabetes tipo 2.
- Identificación de los principales procesos metabólicos aguas arriba que provocan daño cardíaco y renal.
Principales resultados:
- Perturbaciones metabólicas (resistencia a la insulina, inflamación, etc.) son fundamentales para el desarrollo de la ERC, que a menudo preceden a los signos clínicos.
- Existe una relación bidireccional, impulsada por el metabolismo, entre el corazón y los riñones.
Conclusiones:
- El término Met-CVRD refleja con precisión la patología subyacente.
- Es esencial dar prioridad a la detección temprana y al tratamiento con agentes protectores cardiorenales (por ejemplo, agonistas de GLP-1, inhibidores de SGLT2) para un tratamiento proactivo.
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