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Las diferencias étnicas de la pústulosis palmoplantar: una revisión sistemática
Francis Li-Tien Hsu1, Tsen-Fang Tsai2,3,4
1Department of Dermatology, National Taiwan University Hospital, Taipei City, Taiwan.
American journal of clinical dermatology
|September 1, 2025
Resumen
La pustulosis palmoplantar (PPP) muestra variaciones étnicas significativas en su epidemiología, genética, presentación clínica y respuesta al tratamiento. Comprender estas diferencias es clave para el manejo personalizado del paciente.
Área de la Ciencia:
- Dermatología
- Inmunología
- La genética
Sus antecedentes:
- La pustulosis palmoplantar (PPP) es una afección inflamatoria crónica de la piel que afecta las palmas y las plantas de las manos.
- Se conocen variaciones étnicas en las dermatosis inmunomediadas, pero rara vez se estudian para la PPP.
Objetivo del estudio:
- Comparar las diferencias epidemiológicas, genéticas, clínicas y de tratamiento en la PPP entre varias etnias.
Principales métodos:
- Se llevó a cabo una revisión sistemática siguiendo las directrices de PRISMA.
- Busqué en cuatro bases de datos artículos hasta febrero de 2025.
- Síntesis narrativa utilizada debido a la heterogeneidad de los datos.
Principales resultados:
- Se analizaron 101 estudios en los que participaron 216.257 pacientes.
- Se observó una mayor incidencia/prevalencia de PPP en los asiáticos orientales; diferentes tipos clínicos (A frente a B).
- Los factores genéticos (IL36RN, CARD14, HLA), las respuestas al tratamiento y las comorbilidades variaron significativamente según el origen étnico.
Conclusiones:
- Existen diferencias étnicas notables en el perfil genético, las características clínicas y los resultados del tratamiento de la PPP.
- Estos hallazgos subrayan la necesidad de consideraciones étnicas específicas en el diagnóstico y el manejo de la PPP.
- Las estrategias adaptadas que incorporan rasgos étnicos son cruciales para la atención efectiva del paciente.
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