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Presentación inusual: vitiligo segmental concomitante, morfeo segmental y liquen estriado
Zeynep Busra Balik1, Gozde Simsek2, Nur Defne Dogan2
1Department of Dermatology and Venereology, Gülhane Training and Research Hospital, Health Sciences University, Ankara, Turkey. zeynepbusrakucuker@gmail.com.
Irish journal of medical science
|September 1, 2025
Resumen
Este es el primer caso reportado de un paciente que presenta simultáneamente vitiligo segmental, morfeo segmental y liquen estriado. La coincidencia sugiere mecanismos patógenos compartidos como el mosaicismo genético y los desencadenantes autoinmunes en estas distintas condiciones dermatológicas.
Área de la Ciencia:
- Dermatología
- Inmunología
- La genética
Sus antecedentes:
- El vitiligo segmental, la morfeo segmental y el líqueno estriado son afecciones cutáneas distintas.
- Estas condiciones pueden compartir mecanismos subyacentes como el mosaicismo genético y la disfunción del sistema inmunológico.
- La ocurrencia simultánea de estas tres condiciones es excepcionalmente rara.
Objetivo del estudio:
- Para reportar el primer caso de vitiligo segmental concurrente, morfeo segmental y liquen estriado.
- Explorar posibles mecanismos patógenos compartidos y conocimientos etiológicos.
Principales métodos:
- Un caso de una mujer de 24 años con una historia de 6 años de lesiones en la piel.
- El examen clínico reveló despigmentación dermatomal (vitiligo), una mácula de Blaschkoid (lichen striatus) y placas escleróticas (morfeo).
- El examen histopatológico confirmó los diagnósticos distintos para cada condición.
Principales resultados:
- El paciente presentaba la manifestación simultánea de vitiligo segmental, morfeo segmental y liquen estriado.
- La histopatología confirmó la pérdida de melanocitos en el vitíligo, la esclerosis dérmica en la morfea y los cambios epidérmicos con inflamación en el liquen estriado.
Conclusiones:
- Este es el primer caso documentado de vitiligo segmental concurrente, morfeo segmental y liquen estriado.
- Los patrones segmentarios y Blaschkoid observados sugieren un origen común en el mosaicismo genético, potencialmente activado por la autoinmunidad.
- El estudio de esta rara coincidencia puede iluminar las vías inmunopatológicas compartidas.
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