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Urolitina C mejora la hiperuricemia mediante la mitigación de la disfunción renal a través de la supresión del eje
Qingqing Han1,2, Nan Chen2, Kun Peng3
1Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150000, China.
Journal of agricultural and food chemistry
|September 1, 2025
Resumen
La urolitina C reduce efectivamente los niveles altos de ácido úrico (AUH) aumentando la excreción renal y reduciendo el estrés oxidativo. Este metabolito intestinal es prometedor para el manejo de la HUA y la protección de los riñones.
Área de la Ciencia:
- Trastornos del metabolismo
- La microbiota intestinal
- Metabolitos bioactivos
Sus antecedentes:
- La hiperuricemia (HUA) es un trastorno metabólico común con pocas opciones de tratamiento.
- La urolitina C (UroC) es un metabolito derivado de la microbiota intestinal que actúa sobre los alimentos ricos en ellagitanina.
Objetivo del estudio:
- Investigar los efectos y mecanismos de la UroC en la gestión de la HUA.
- Para comparar UroC con sus análogos UroA y UroB en el tratamiento de HUA.
Principales métodos:
- Análisis UFLC-MS/MS para identificar la forma activa del UroC in vivo.
- Estudios in vivo con ratones HUA para evaluar el impacto de UroC en los niveles séricos de ácido úrico (SUA).
- Estudios mecánicos que incluyen estrés oxidativo, marcadores de fibrosis y la vía de señalización ROS-p38/ERK MAPK.
Principales resultados:
- UroC redujo significativamente los niveles de SUA en ratones HUA, superando a UroA y UroB.
- La UroC libre fue identificada como la forma activa primaria in vivo.
- UroC mejora la excreción renal de ácido úrico, reduce el estrés oxidativo renal y la fibrosis.
- UroC inhibió la activación de la p38 / ERK MAPK inducida por la UA al disminuir la producción de ROS.
- Los experimentos de rescate confirmaron el mecanismo de UroC que involucra a los transportadores de UA y los marcadores de fibrosis a través de la inhibición de p38/ERK MAPK.
Conclusiones:
- La urolitina C es un potente metabolito derivado de los alimentos para el tratamiento de la hiperuricemia.
- UroC promueve la protección renal y mejora la excreción de ácido úrico a través de la vía ROS-p38/ ERK MAPK.
- UroC representa un candidato terapéutico prometedor para el tratamiento de la hiperuricemia.
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