Video Experimental Relacionado
Updated: Sep 9, 2025
04:13
Less-Invasive Technique for Non-stabilized Mandibular Fracture in Mouse Models
Published on: September 27, 2024
450
Buvidal/Brixadi - una formulación inyectable de buprenorfina de acción prolongada para el tratamiento de la
Nicholas Lintzeris1,2,3, Adrian J Dunlop3,4,5,6
1Specialty of Addiction Medicine, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Pain management
|September 2, 2025
Resumen
La buprenorfina inyectable de acción prolongada, como Buvidal (Brixadi), ofrece un tratamiento nuevo y eficaz para la dependencia de opiáceos. Esta formulación de liberación prolongada ofrece una alternativa segura a la administración diaria para el tratamiento del trastorno por consumo de opiáceos.
Área de la Ciencia:
- Farmacología
- Medicina para la adicción
- Farmacia clínica
Sus antecedentes:
- La dependencia de opiáceos es una enfermedad crónica recurrente que requiere un tratamiento eficaz a largo plazo.
- Los tratamientos tradicionales a menudo implican dosis diarias, lo que puede presentar desafíos de adherencia.
Objetivo del estudio:
- Revisar las formulaciones inyectables de buprenorfina de acción prolongada para el tratamiento de la dependencia de opiáceos.
- Examinar la eficacia, la seguridad y la aplicación clínica de Buvidal (Brixadi).
Principales métodos:
- Revisión de la literatura de los estudios sobre la buprenorfina inyectable de liberación prolongada.
- Análisis de las propiedades farmacológicas, datos de ensayos clínicos y directrices de tratamiento.
Principales resultados:
- La buprenorfina inyectable de acción prolongada proporciona niveles terapéuticos sostenidos de buprenorfina.
- Los estudios clínicos demuestran una eficacia y seguridad comparables a la dosis diaria, con una mejor adherencia.
- Se discuten consideraciones específicas para el control del dolor, el embarazo y los entornos de custodia.
Conclusiones:
- La buprenorfina inyectable de liberación prolongada representa un avance significativo en el tratamiento de la dependencia de opiáceos.
- Esta formulación ofrece una alternativa segura, eficaz y conveniente a los regímenes de dosificación diaria.
- Amplía las opciones de tratamiento para el trastorno por consumo de opiáceos, mejorando la atención y los resultados del paciente.
Videos de Conceptos Relacionados
01:15Opioid Analgesics: Synthetic and Semisynthetic Opioids
421
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
421
01:22Opioid Receptors: Overview
1.8K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
1.8K
01:25Analgesia and Pain Management
788
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
788
01:20Opioid Analgesics: Morphine and Other Natural Cogeners
361
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
361
01:17Drug Dependence
1.2K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.2K
01:15Drug Abuse and Addiction: Pharmacological Phenomena
655
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
655