Abrir la barrera hematoencefálica: un desafío para el suministro local de fármacos terapéuticos
Ver abstracta en PubMed
Resumen
Este resumen es generado por máquina.Este artículo ha pasado la revisión por pares y ha sido aceptado para su publicación en Radiology. Se someterá a ediciones finales antes de la publicación, y pueden ocurrir posibles cambios de contenido.
Área De La Ciencia
- Radiología
- Imágenes médicas
- Proceso de revisión por pares
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- Los manuscritos enviados a Radiología se someten a una rigurosa revisión por pares.
- Los artículos aceptados pasan a una fase de producción que incluye la edición y el diseño.
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The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Overview
The blood-brain barrier (BBB) refers to the specialized vasculature that provides the brain with nutrients in the blood while strictly regulating the movement of ions, molecules, pathogens, and other substances. It is composed of tightly linked endothelial cells on one side and astrocyte projections on the other. Together they provide a semipermeable barrier that protects the brain and poses unique challenges to the delivery of therapeutics.
Cellular Components
The BBB is made up of...
Drug distribution in the body is intricately regulated by various physiological barriers that control the passage of substances. These include the capillary endothelial barrier, the blood-brain, blood-cerebrospinal fluid, blood-placental, and blood-testis barriers.
The capillary endothelial barrier allows only smaller molecules below 600 Da (Daltons) to pass through. It also restricts drugs like heparin that are bound to blood components, limiting their movement within the bloodstream.
The...
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
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