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Interrupción de la corregulación fisiológica en jóvenes con alto riesgo clínico de psicosis: información de un
Alison M Schreiber1, Matías Martinez2, Sharon Li2
1Department of Psychiatry, University of Kentucky.
Emotion (Washington, D.C.)
|September 2, 2025
Resumen
Los jóvenes con alto riesgo clínico de psicosis (CHR) muestran respuestas fisiológicas inusuales durante las conversaciones con los cuidadores. Esta corregulación contraria está relacionada con el aumento de los síntomas de la psicosis con el tiempo.
Área de la Ciencia:
- Psicofisiología
- Psicología clínica
- Neurociencia del desarrollo
Sus antecedentes:
- Las dificultades interpersonales están relacionadas con la psicopatología.
- Los correlatos fisiológicos de la desconexión social en las poblaciones clínicas, especialmente los jóvenes con alto riesgo clínico de psicosis (CHR), no se comprenden bien.
Objetivo del estudio:
- Examinar la corregulación fisiológica en tiempo real en los jóvenes de CHR y sus cuidadores.
- Para vincular los patrones de corregulación con síntomas clínicos concurrentes y prospectivos.
Principales métodos:
- Estudio basado en el laboratorio en el que participaron 70 diadas (32 cuidadores de jóvenes con CHR, 38 cuidadores de jóvenes sanos).
- Monitoreo fisiológico autónomo continuo durante conversaciones neutras, conflictivas y agradables.
- Datos recopilados entre 2018-2022 en una ciudad del Medio Oeste.
Principales resultados:
- Los jóvenes de CHR mostraron corregulación fisiológica contraria (por ejemplo, cambios en la frecuencia cardíaca opuestos al cuidador) durante las conversaciones de conflicto y neutrales.
- La corregulación contraria se asoció con un riesgo elevado de psicosis y síntomas iniciales.
- Este patrón predijo un aumento de los síntomas un año después.
Conclusiones:
- Los hallazgos revelan una alteración de la corregulación fisiológica en las díadas CHR de jóvenes y cuidadores.
- Estas alteraciones son relevantes para la sintomatología clínica y el riesgo de psicosis.
- Sugiere el potencial para las intervenciones centradas en las relaciones y promueve una comprensión biológicamente fundamentada de la conexión social.
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