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Protocolo de estudio para un ensayo clínico controlado aleatorio de un programa de entrenamiento cognitivo

Carlos González-Pérez¹, Eduardo Fernández-Jiménez^2,3,4, Elena Moran⁵

¹Department of Pediatric Hemato-Oncology, La Paz University Hospital, Madrid, Spain.

|September 2, 2025

Resumen

Este estudio prueba si los videojuegos pueden mejorar la función cerebral y la salud en los sobrevivientes de cáncer infantil. El entrenamiento cognitivo tiene como objetivo mejorar los marcadores neuropsicológicos, neurológicos e inmunológicos, mejorando la calidad de vida de los sobrevivientes.

Área de la Ciencia:

Oncología pediátrica
La neurociencia
Inmunología

Sus antecedentes:

Los sobrevivientes de cáncer infantil a menudo experimentan déficits neurocognitivos a largo plazo.
Los tratamientos contra el cáncer como la quimioterapia y la radiación pueden afectar negativamente la salud del cerebro.
Se necesitan intervenciones eficaces para gestionar estas secuelas.

Objetivo del estudio:

Evaluar la eficacia de un programa de entrenamiento cognitivo basado en videojuegos.
Evaluar las mejoras en los parámetros neuropsicológicos, neurológicos, inmunológicos e inflamatorios.
Para mejorar la calidad de vida de los sobrevivientes de cáncer infantil.

Principales métodos:

Un ensayo controlado aleatorizado en el que participaron 56 sobrevivientes de cáncer infantil (entre 8 y 17 años).
Los participantes son asignados al azar a una intervención de videojuego o a un grupo de control de lista de espera.
Los resultados primarios incluyen cambios en las pruebas neurocognitivas, neuroimagen y biomarcadores.

Principales resultados:

Esta sección se completará una vez finalizado el estudio.
Los resultados detallarán los cambios en la función cognitiva, la estructura / actividad cerebral y los marcadores inmunológicos.
El análisis también abarcará la autopercepción psicológica y la viabilidad de la intervención.

Conclusiones:

Este estudio proporcionará información sobre el manejo de secuelas neurocognitivas en sobrevivientes de cáncer infantil.
El entrenamiento cognitivo basado en videojuegos puede ofrecer un nuevo enfoque para la rehabilitación.
Los hallazgos tienen por objeto mejorar los resultados a largo plazo y la calidad de vida de esta población.

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