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Updated: Sep 9, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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Mecanismos subyacentes a la modulación alostérica del medicamento anticonvulsivo que se une a la proteína de la

Anshumali Mittal1, Matthew F Martin1, Laurent Provins2

  • 1Department of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15213.

Proceedings of the National Academy of Sciences of the United States of America
|September 2, 2025
PubMed
Resumen

UCB1244283 mejora alostericamente la unión de los medicamentos anticonvulsivos a la proteína 2A de las vesículas sinápticas (SV2A). Este descubrimiento revela un nuevo sitio de unión y red, allanando el camino para nuevas terapias dirigidas a SV2A.

Palabras clave:
alosteríaProteínas de membranafarmacologíaBiología estructural

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