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Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
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Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
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Los péptidos artificiales como moduladores de la autofagia

Yuhai Cai1, Ling Qiu1, Boyu Zhang1

  • 1Center for Innovative Drug Discovery, Greater Bay Area Institute of Precision Medicine (Guangzhou), School of Pharmacy, Fudan University, Shanghai, P. R. China.

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|September 2, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los péptidos artificiales ofrecen un nuevo enfoque para modular la autofagia, un proceso celular clave. Esta revisión destaca los avances en las herramientas basadas en péptidos para monitorear, inducir e inhibir la autofagia para el potencial terapéutico.

Palabras clave:
Regulador de la autofagiael cáncermodificación químicadesarrollo de drogasPeptídeo

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Área de la Ciencia:

  • Biología celular
  • La bioquímica
  • La medicina molecular

Sus antecedentes:

  • La autofagia es un proceso celular fundamental crucial para mantener la homeostasis.
  • La desregulación de la autofagia está relacionada con enfermedades importantes como el cáncer, la neurodegeneración y las infecciones.
  • Dirigirse a la autofagia presenta una vía terapéutica prometedora.

Objetivo del estudio:

  • Revisar los avances recientes en los moduladores de autofagia basados en péptidos artificiales.
  • Explorar herramientas de péptidos para monitorear, inducir e inhibir la autofagia.
  • Para discutir el potencial de estos péptidos como agentes terapéuticos.

Principales métodos:

  • Revisión de la literatura sobre los moduladores de la autofagia basados en péptidos artificiales.
  • Análisis de estudios sobre herramientas peptídicas para el monitoreo de la autofagia.
  • Examen de la investigación sobre los inductores e inhibidores de la autofagia basados en péptidos.

Principales resultados:

  • Los péptidos artificiales se muestran prometedores como alternativas específicas y biocompatibles a las moléculas pequeñas.
  • Las herramientas emergentes basadas en péptidos ofrecen estrategias versátiles para la modulación de la autofagia.
  • Los avances recientes incluyen nuevas estrategias de monitoreo, inducción e inhibición.

Conclusiones:

  • Los moduladores basados en péptidos artificiales representan un avance significativo en la investigación de la autofagia.
  • Estos péptidos ofrecen ventajas en cuanto a especificidad y biocompatibilidad para aplicaciones terapéuticas.
  • El desarrollo posterior tiene potencial para el tratamiento de enfermedades relacionadas con la autofagia.