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Updated: Sep 9, 2025

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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Las diferencias individuales dan forma a la representación conceptual en el cerebro

Matteo Visconti di Oleggio Castello1,2, Tom Dupré la Tour1, Jack L Gallant1,2

  • 1Helen Wills Neuroscience Institute, University of California, Berkeley; Berkeley, CA 94720, USA.

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Resumen

Los científicos desarrollaron un nuevo marco estadístico para medir las diferencias cerebrales individuales en la representación conceptual. Este enfoque revela sesgos cerebrales específicos de la persona, allanando el camino para la neurociencia de precisión y la medicina personalizada para los trastornos cognitivos.

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Área de la Ciencia:

  • La neurociencia cognitiva
  • Imágenes neurológicas
  • Diferencias individuales

Sus antecedentes:

  • Las experiencias individuales dan forma a una comprensión conceptual única, sin embargo, estas diferencias son difíciles de medir en la neurociencia cognitiva.
  • Esto limita la medicina de precisión para los trastornos cognitivos.
  • Los métodos existentes luchan por capturar las representaciones funcionales del cerebro específicas de la persona.

Objetivo del estudio:

  • Desarrollar un nuevo marco estadístico para medir e interpretar las diferencias individuales en las representaciones funcionales del cerebro.
  • Para caracterizar cómo los individuos distintos representan los mismos conceptos en sus cerebros.
  • Para establecer un nuevo paradigma para la neurociencia de precisión.

Principales métodos:

  • La resonancia magnética funcional (fMRI) se utilizó para medir la actividad cerebral en 24 participantes que escuchaban historias narrativas.
  • Se emplearon modelos de codificación para decodificar las representaciones conceptuales de los datos de IRMf.
  • Se realizó un análisis estadístico para identificar diferencias individuales sistemáticas en estas representaciones.

Principales resultados:

  • Se observaron sesgos sistemáticos y específicos de la persona en las representaciones conceptuales del cerebro, a pesar de los estímulos idénticos.
  • La variabilidad individual fue más pronunciada en las regiones cerebrales asociadas con el procesamiento de información social.
  • Estas diferencias se correlacionan con la integración de la información sensorial y las creencias / experiencias personales.

Conclusiones:

  • Las diferencias individuales en las representaciones conceptuales del cerebro son sistemáticas y medibles.
  • El marco desarrollado permite el estudio de mapas cerebrales funcionales específicos de la persona.
  • Esta investigación proporciona una base para la neurociencia de precisión y las aplicaciones de IRMf en la medicina de precisión para los trastornos cognitivos.