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El MERS-CoV antagoniza la activación de PKR inhibiendo su condensación en los complejos de replicación viral

Ebba K Blomqvist, Nicole Bracci, Helena Winstone

    bioRxiv : the preprint server for biology
    |September 2, 2025
    PubMed
    Resumen

    El coronavirus del síndrome respiratorio del Medio Oriente (MERS-CoV) se opone a la vía de la proteína quinasa R (PKR). La proteína NS4a del MERS-CoV previene la activación de PKR al bloquear la condensación de PKR en el ARNd viral, un paso crucial para la inmunidad innata.

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