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La retención de intrón regula la función STAT2 y predice la respuesta a la inmunoterapia en el cáncer de pulmón

Ryan P Englander1,2, Mattia Brugiolo1, Te-Chia Wu1

  • 1The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

bioRxiv : the preprint server for biology
|September 2, 2025
PubMed
Resumen

El splicing de ARN alternativo afecta la inmunidad tumoral y la respuesta a la inmunoterapia en el cáncer de pulmón. La retención específica de intrones STAT2 predice la respuesta del paciente a los inhibidores del punto de control, ofreciendo potenciales biomarcadores.

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