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Evaluación prospectiva de la neurocognición en pacientes tras el reemplazo de la válvula aórtica transcatéter
Srinivasa P Potluri1, Cody W Dorton2, Kyle A McCullough2
1Department of Cardiology, Baylor Scott & White The Heart Hospital, Plano, Texas, USA.
Structural heart : the journal of the Heart Team
|September 2, 2025
Resumen
El reemplazo de la válvula aórtica transcatéter (TAVR) mejoró significativamente la función neurocognitiva en pacientes con deterioro cognitivo leve (MCI) hasta 6 meses después del procedimiento. TAVR es una opción segura para la enfermedad de la válvula aórtica en pacientes con MCI.
Área de la Ciencia:
- Cardiología
- Neurología
- Enfermedad de los ancianos
Sus antecedentes:
- Existen datos contradictorios sobre los cambios neurocognitivos después del reemplazo de la válvula aórtica transcatéter (TAVR).
- Este estudio se centró en pacientes con deterioro cognitivo leve (MCI) sometidos a TAVR.
- La investigación de los cambios cognitivos hasta 6 meses después del TAVR es crucial.
Objetivo del estudio:
- Investigar el cambio en la función neurocognitiva en pacientes con deterioro cognitivo leve (MCI) hasta 6 meses después del reemplazo de la válvula aórtica transcatéter (TAVR).
Principales métodos:
- Estudio de cohorte prospectivo, observacional y no aleatorizado.
- Incluidos los pacientes con TAVR con MCI (puntuación en la Evaluación Cognitiva de Mini-Montreal [Mini MoCA] ≤25/30).
- Mini MoCA evaluado antes del TAVR, 30 días y 6 meses después del TAVR.
Principales resultados:
- Aumento significativo de la puntuación Mini MoCA a los 30 días (p < 0,001) y a los 6 meses (p < 0,001) después del TAVR.
- Mejora cognitiva observada en el 64,4% a los 30 días y en el 89,4% a los 6 meses.
- Aumento promedio de 2,3 puntos en las puntuaciones de Mini MoCA a los 6 meses en comparación con el valor basal.
Conclusiones:
- El reemplazo de la válvula aórtica transcatéter (TAVR) conduce a una mejora neurocognitiva significativa en pacientes con deterioro cognitivo leve basal (MCI).
- La Evaluación Cognitiva Mini-Montreal (Mini MoCA) mide efectivamente estos cambios cognitivos.
- TAVR es una opción terapéutica segura y efectiva para pacientes con enfermedad de la válvula aórtica y MCI.
Palabras clave:
Estenosis de la aortaReemplazo de la válvula aórticaLas funciones cognitivasDeterioro cognitivo leveEvaluación cognitiva de MontrealEl TAVRMás Videos Relacionados
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