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Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Acute Pyelonephritis II: Diagnostic Studies and Management01:28

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Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
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Updated: Sep 9, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Informe de caso: Leucopenia reversible asociada a la polimixina E

Suxin Wan1, Jia-Quan Zhu2, Lihua Wang3

  • 1Department of Pharmacy, Chongqing University Three Gorges Hospital, Chongqing University, Chongqing, China.

Frontiers in immunology
|September 2, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La polimixina E, un antibiótico de último recurso, puede causar leucopenia (bajo recuento de glóbulos blancos). Este estudio de caso pone de relieve la importancia de controlar los recuentos sanguíneos durante el tratamiento para garantizar la seguridad del paciente.

Área de la Ciencia:

  • Enfermedades infecciosas
  • Farmacología
  • Hematología

Sus antecedentes:

  • La polimixina E es un antibiótico crítico para las infecciones bacterianas multirresistentes.
Palabras clave:
En el caso de las bacterias Klebsiella pneumoniainforme de casoLeucopenia y leucemiaLa polimixinaPolymyxin E, también conocido como polymyxin

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  • Los efectos adversos de la polimixina E incluyen nefrotoxicidad y neurotoxicidad.
  • La leucopenia es un efecto adverso potencial, aunque menos comúnmente reportado.