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Células progenitoras, microglia y ARN no codificantes: Orquestradores de la patogénesis del glioblastoma y de la
Adil Husain1, Firoz Ahmad2, Sandeep Pandey3
1Department of Biochemistry, Babu Banarasi Das College of Dental Sciences, Babu Banarasi Das University, Lucknow, 226028, Uttar Pradesh, India.
Non-coding RNA research
|September 2, 2025
Resumen
El glioblastoma (GB) es agresivo y resistente al tratamiento. Las células progenitoras, la microglía y los ARN no codificantes (ARNnc) impulsan el crecimiento y la resistencia de GB, ofreciendo nuevos objetivos terapéuticos.
Área de la Ciencia:
- Neuro-oncología
- Biología del cáncer
- Biología molecular
Sus antecedentes:
- El glioblastoma (GB) presenta desafíos terapéuticos significativos debido a su naturaleza agresiva y resistencia a los tratamientos estándar.
- Las células madre de glioma (GSC), originadas en células progenitoras, son los factores clave para el inicio del tumor, la recurrencia y la resistencia al tratamiento.
- Las células inmunes del cerebro, microglia, son manipuladas por GB para fomentar un entorno inmunosupresor, promoviendo la progresión del tumor y la evasión de la terapia.
Objetivo del estudio:
- Revisar las funciones complejas de las células progenitoras, la microglía y los ARN no codificantes (ARNc) en la patogénesis del glioblastoma.
- Para aclarar cómo estos componentes contribuyen a la resistencia a la terapia en el glioblastoma.
- Explorar nuevas estrategias terapéuticas dirigidas a estos agentes moleculares para mejorar los resultados del tratamiento del glioblastoma.
Principales métodos:
- Revisión de la literatura centrada en el glioblastoma, las células progenitoras, la microglía y los ARN no codificantes.
- Análisis de los mecanismos moleculares subyacentes al inicio, la progresión y la resistencia del glioblastoma.
- Síntesis de las investigaciones actuales sobre la interacción entre los componentes celulares y los ncRNA en el microambiente del glioblastoma.
Principales resultados:
- Las células progenitoras (como GSC) exhiben plasticidad y impulsan la recurrencia y la resistencia del tumor.
- Las células del glioblastoma cooptan la microglía para crear un microambiente tumoral inmunosupresor.
- Los ARN no codificantes (miARN, lncARN) regulan la expresión génica y modulan las interacciones, influyendo en los mecanismos de resistencia.
Conclusiones:
- Comprender las funciones intrincadas de las células progenitoras, la microglía y el ncRNA es crucial para abordar el glioblastoma.
- Dirigirse a estas vías interconectadas ofrece estrategias prometedoras para superar la resistencia a la terapia del glioblastoma.
- Investigaciones adicionales sobre estos agentes moleculares pueden conducir a mejores resultados clínicos en pacientes con glioblastoma.
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