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FungiSNC: Una base de datos integrada para pequeños ARN no codificantes de hongos basados en secuenciación de alto
Xiaoqiang Lang1, Jinjing Luo2, Fazhi Li1
1Microbiology and intelligent biomanufacturing Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, Sichuan 610041, China.
Journal of advanced research
|September 2, 2025
Resumen
FungiSNC es la primera base de datos integrada para ARN pequeños no codificantes de hongos (ARNc), que ofrece herramientas de análisis integrales. Esta plataforma ayuda a comprender las funciones del sncRNA y las redes reguladoras en los hongos para aplicaciones antifúngicas y de control biológico.
Área de la Ciencia:
- Micología
- La bioinformática
- La genómica
Sus antecedentes:
- Los pequeños ARN no codificantes (ARNnc) son reguladores vitales en el desarrollo de hongos, respuestas al estrés y patogenicidad.
- Las bases de datos existentes carecen de capacidades completas de integración y análisis para los datos de secuenciación de sncRNA de hongos.
- Actualmente no se dispone de una plataforma dedicada para los sncRNA de hongos y sus funciones.
Objetivo del estudio:
- Establecer FungiSNC, la primera base de datos integrada para los sncRNA de hongos.
- Proporcionar una plataforma completa para diversas categorías de sncRNA en hongos.
- Facilitar el análisis y la exploración de las funciones del sncRNA fúngico.
Principales métodos:
- Flujo de trabajo estandarizado para el preprocesamiento de datos de conjuntos de datos sRNA-seq públicos e internos.
- Detección sistemática, clasificación y anotación funcional de los sncRNA.
- Integración de los resultados en una base de datos relacional con herramientas analíticas integradas.
Principales resultados:
- FungiSNC se presenta como una base de datos integrada para los sncRNA de hongos.
- Abarca diversas categorías de sncRNA: siRNAs, milRNAs, phasiRNAs, rRNAs, tRNAs, snRNAs, snoRNAs, piRNAs y tRFs.
- La base de datos agrega 989 muestras de NGS de 29 especies de hongos.
Conclusiones:
- FungiSNC es la plataforma inaugural para la curación, anotación y análisis funcional de datos de sncRNA de hongos.
- Conecta datos fragmentados con herramientas computacionales para explorar las redes reguladoras de sncRNA en hongos.
- Los hallazgos tienen implicaciones para la terapia antifúngica y las estrategias de biocontrol agrícola.
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