Identificación escasa de las ecuaciones de gobierno en sistemas de motivación biológica

Mehrdad Anvari1, Hamidreza Marasi2, Hossein Kheiri1

  • 1Department of Applied Mathematics, Faculty of Mathematics, Statistics, and Computer Science, University of Tabriz, Tabriz, 51666-16471, Iran.

Scientific reports
|September 2, 2025
PubMed
Resumen

Un nuevo marco IRK-SINDy utiliza métodos implícitos de Runge-Kutta para identificar de manera robusta las ecuaciones rectoras a partir de datos escasos y ruidosos. Este enfoque basado en datos mejora el descubrimiento de modelos en sistemas físicos y biológicos complejos.

Videos de Conceptos Relacionados

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
100
Linear Approximation in Time Domain01:21

Linear Approximation in Time Domain

Nonlinear systems often require sophisticated approaches for accurate modeling and analysis, with state-space representation being particularly effective. This method is especially useful for systems where variables and parameters vary with time or operating conditions, such as in a simple pendulum or a translational mechanical system with nonlinear springs.
For a simple pendulum with a mass evenly distributed along its length and the center of mass located at half the pendulum's length,...
124
Linear Approximation in Frequency Domain01:26

Linear Approximation in Frequency Domain

Linear systems are characterized by two main properties: superposition and homogeneity. Superposition allows the response to multiple inputs to be the sum of the responses to each individual input. Homogeneity ensures that scaling an input by a scalar results in the response being scaled by the same scalar.
In contrast, nonlinear systems do not inherently possess these properties. However, for small deviations around an operating point, a nonlinear system can often be approximated as linear....
131
Euler Equations of Motion01:19

Euler Equations of Motion

Imagine a rigid body that is rotating at an angular velocity of ω within an inertial frame of reference. Along with this, picture a second rotating frame that is attached to the body itself. This frame moves along with the body and possesses an angular velocity of Ω. The total moment about the center of mass is calculated by adding the rate of change of angular momentum about the center of mass in relation to the rotating frame and the cross-product of the body's angular velocity...
321
Transmission-Line Differential Equations01:26

Transmission-Line Differential Equations

Transmission lines are essential components of electrical power systems. They are characterized by the distributed nature of resistance (R), inductance (L), and capacitance (C) per unit length. To analyze these lines, differential equations are employed to model the variations in voltage and current along the line.
Line Section Model
A circuit representing a line section of length Δx helps in understanding the transmission line parameters. The voltage V(x) and current i(x) are measured...
401
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
708