Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

2.8K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
2.8K
Multi-pass Transmembrane Proteins and β-barrels01:09

Multi-pass Transmembrane Proteins and β-barrels

5.5K
In multi-pass transmembrane proteins, the polypeptide chain crosses the membrane more than once. The transmembrane polypeptide chain either forms an α-helix or β-strand structure. α-Helix containing multi-pass transmembrane proteins are ubiquitous, whereas β-strand containing ones are mainly found in gram-negative bacteria, mitochondria, and chloroplasts.
α-Helix containing multi-pass transmembrane proteins
Multi-pass transmembrane proteins such as...
5.5K
Mechanisms of Membrane Domain Formation00:59

Mechanisms of Membrane Domain Formation

3.1K
Different physical properties of lipids and proteins allow them to localize and form distinct islands or domains in the membrane. Some membrane domains are formed due to protein-protein interactions, whereas others are formed due to the presence of specific lipids such as sphingolipids and sterols—for example, large proteins, such as bacteriorhodopsin, aggregate and create distinct domains.
Another mechanism for membrane domain formation involves membrane proteins interacting with...
3.1K
Fluid Mosaic Model01:19

Fluid Mosaic Model

12.8K
Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
12.8K
Membrane Domains01:18

Membrane Domains

5.7K
The membrane domains concentrate specific lipids and proteins at one place within the membrane, which helps in cell signaling, adhesion, and other critical cellular processes. These domains can differ in size, composition, function, and lifespan.
Protein Domains
The membrane comprises a group of distinct proteins responsible for carrying out a cell's specific function. For example, the plasma membrane of the human sperm, or a single germ cell, contains a unique set of proteins in the...
5.7K
Single-pass Transmembrane Proteins01:25

Single-pass Transmembrane Proteins

5.3K
Integral membrane proteins are tightly associated with the cell membrane and play a crucial role in cell communication, signaling, adhesion, and transport of the molecules. Some integral membrane proteins are present only in the membrane monolayer. For example, the enzyme fatty acid amide hydrolase is present in the cytoplasmic side of the membrane monolayer. In contrast, another type of integral membrane protein, also known as a transmembrane protein, spans across the membrane. Transmembrane...
5.3K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Active nuclear positioning and actomyosin contractility maintain leader cell integrity during gonadogenesis.

Current biology : CB·2024
Same author

Protocol for neuron tracing and analysis of dendritic structures from noisy microscopy images using Neuronalyzer.

STAR protocols·2024
Same author

Directed cell invasion and asymmetric adhesion drive tissue elongation and turning in C. elegans gonad morphogenesis.

Developmental cell·2022
Same author

Thy1 marks a distinct population of slow-cycling stem cells in the mouse epidermis.

Nature communications·2022
Same author

A role for endoplasmic reticulum dynamics in the cellular distribution of microtubules.

Proceedings of the National Academy of Sciences of the United States of America·2022
Same author

Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans.

PLoS computational biology·2021

Video Experimental Relacionado

Updated: Sep 9, 2025

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

2.3K

Clasificación: Ciencias Biológicas - Biofísica y Biología Computacional Morfologías de membrana que surgen de estados

Avihay Kadosh1, Tom Shemesh1

  • 1Faculty of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel.

Biophysical journal
|September 3, 2025
PubMed
Resumen

La forma de la membrana celular está influenciada por las proteínas que cambian su forma. Este estudio revela cómo la flexibilidad de las proteínas impulsa la organización de la membrana y los cambios de forma, impactando las funciones celulares.

Palabras clave:
EstabilidadDos capas de lípidosCurvatura de la membranaProteínas de membranaProteínas de varios estados

Más Videos Relacionados

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.5K
Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
10:49

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

Published on: March 5, 2017

13.4K

Videos de Experimentos Relacionados

Last Updated: Sep 9, 2025

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions
06:32

Reconstitution of Septin Assembly at Membranes to Study Biophysical Properties and Functions

Published on: July 28, 2022

2.3K
Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
07:31

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches

Published on: September 1, 2023

2.5K
Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy
10:49

Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy

Published on: March 5, 2017

13.4K

Área de la Ciencia:

  • Biología celular
  • La biofísica
  • Modelado computacional

Sus antecedentes:

  • Las membranas celulares exhiben geometrías complejas cruciales para la función.
  • Se sabe que las proteínas estabilizadoras de curvatura esculpen formas de membrana.
  • El papel de los cambios conformacionales de las proteínas en la configuración de la membrana es en gran medida desconocido.

Objetivo del estudio:

  • Investigar cómo las proteínas de membrana con múltiples conformaciones dan forma colectiva a las membranas biológicas.
  • Explorar las implicaciones de la flexibilidad conformacional de las proteínas en la mecánica y organización de las membranas.
  • Proporcionar una visión fundamental de la organización funcional de los sistemas de membranas biológicas.

Principales métodos:

  • Modelado físico basado en el continuo.
  • Desarrollo de un esquema de discretización de la forma basado en la curvatura para una representación eficiente de la geometría.
  • Simulación de membranas con proteínas multiestado incrustadas.

Principales resultados:

  • La flexibilidad conformacional de las proteínas de membrana puede conducir a comportamientos emergentes como la biestabilidad mecánica y la organización colectiva.
  • Las membranas con proteínas de varios estados pueden adoptar espontáneamente formas no uniformes.
  • Los cambios de forma son impulsados por el patrón espacial o la redistribución de los estados conformacionales de las proteínas.

Conclusiones:

  • Las proteínas de varios estados juegan un papel crítico en la orquestación de cambios morfológicos de la membrana a gran escala.
  • La dinámica conformacional de las proteínas ofrece un mecanismo fundamental para la organización de la membrana biológica.
  • Este trabajo proporciona nuevos conocimientos sobre la adaptabilidad funcional de las membranas celulares.