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Asociación entre la concentración media ponderada en el tiempo de la glucosa o la variabilidad de la glucosa y la
Jiaxin Ren1, Ge Wang1, Yizhe Zhou1
1Division of Cardiology, Center for Coronary Artery Disease, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Renal failure
|September 3, 2025
Resumen
El control glucémico intensivo puede prevenir la lesión renal aguda (IRA) en pacientes con enfermedad arterial coronaria (EAC) y prediabetes. La gestión de la variabilidad de la glucosa es clave para reducir el riesgo de IAC en esta población.
Área de la Ciencia:
- Cardiología
- Nefrología
- Endocrinología
Sus antecedentes:
- La enfermedad de las arterias coronarias (CAD) y la prediabetes son factores de riesgo significativos para las complicaciones cardiovasculares y renales.
- La lesión renal aguda (IRA) es una preocupación grave en pacientes con CAD comórbido y prediabetes.
- Las estrategias eficaces para la prevención de las IAC en esta población de alto riesgo son cruciales.
Objetivo del estudio:
- Validar la eficacia del control glucémico intensivo en la prevención de la IAC en pacientes con EAC y prediabetes.
- Investigar la asociación entre las métricas de control glucémico y la aparición de IAC.
- Evaluar el papel de la variabilidad de la glucosa en el riesgo de IAC.
Principales métodos:
- Se utilizaron datos de la base de datos Prospective Registry of the Current Status of Care for Patients with CAD (Registro prospectivo del estado actual de la atención para pacientes con CAD).
- Control glucémico evaluado utilizando la glucosa media ponderada en el tiempo (TWAG) y el coeficiente de variación de la glucosa (CV).
- Se analizó el resultado primario de la ocurrencia de IAC en 2.454 pacientes con CAD con prediabetes.
Principales resultados:
- Cada aumento de 1 mmol/ L en el TWAG se asoció con una incidencia 1, 50 veces mayor de AKI (OR: 1, 35-1, 67) después del ajuste.
- Un aumento de 0,1 unidades en la glucosa CV se relacionó con un riesgo aproximadamente un 44% mayor de IAC.
- Tanto la TWAG como la CV se correlacionaron de forma independiente y positiva con el riesgo de IAC de una manera dependiente de la dosis.
Conclusiones:
- Existe una asociación entre TWAG o CV de glucosa y AKI en individuos con CAD y prediabetes.
- Los hallazgos sugieren un valor potencial en el monitoreo continuo de la glucosa para la reducción del riesgo de IAC.
- La gestión de la variabilidad glucémica puede ser una estrategia crítica para mitigar el AKI en este grupo de pacientes.
Palabras clave:
Lesión renal agudaEnfermedad arterial coronariaConcentración de glucosaVariabilidad de la glucosaLa prediabetes también es muy frecuente.Más Videos Relacionados
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