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¿Merecía la pena? Datos de respuesta de más de 650 participantes estadounidenses e internacionales en ensayos de

David Zahrieh¹, Carrie A Strand², Paul J Limburg³

¹Mayo Clinic, Rochester, United States.

Cancer prevention research (Philadelphia, Pa.)

|September 3, 2025

Resumen

La satisfacción de los participantes en los ensayos de quimioprevención en fase inicial fue alta en general (85%). Sin embargo, los participantes de raza negra/asiática y aquellos que experimentaron eventos adversos o terminación prematura informaron una menor satisfacción, destacando áreas para mejorar el ensayo.

Área de la Ciencia:

Ensayos clínicos
Investigación en la prevención del cáncer
Resultados informados por los pacientes

Sus antecedentes:

Los ensayos de quimioprevención en fase temprana son cruciales para el desarrollo de nuevas estrategias de prevención del cáncer.
Comprender la satisfacción de los participantes es vital para mejorar la acumulación, la retención y la adherencia del ensayo.
Las investigaciones anteriores no han explorado ampliamente los factores de satisfacción en este entorno de ensayo específico.

Objetivo del estudio:

Evaluar la satisfacción de los participantes en los ensayos de quimioprevención en fase inicial.
Identificar los factores demográficos y relacionados con el ensayo asociados con la satisfacción de los participantes.

Principales métodos:

Análisis de los datos de 13 ensayos de quimioprevención en fase temprana de la Red de Prevención del Cáncer (2006-2021).
Administración de los 5 artículos "¿Vale la pena?" (WIWI) para evaluar la satisfacción general.
Análisis estadístico para identificar predictores de la satisfacción general entre 652 participantes de diferentes grupos demográficos y experiencias de ensayo.

Principales resultados:

El 85% de los participantes manifestó su satisfacción general.
La menor satisfacción se asoció significativamente con el origen étnico negro/asiático/>1 (OR 2,96, P<0,001) en comparación con los participantes blancos, no hispanos/latinos.
El aumento de las probabilidades de insatisfacción se relacionó con la experiencia de eventos adversos previos a la intervención (OR 1.9, P=0.012), eventos adversos prolongados durante la intervención (OR 1.8, P=0.024) y terminación temprana del ensayo (OR 7.4, P<0.001).

Conclusiones:

Si bien la satisfacción general es alta, los subgrupos y experiencias específicos tienen un impacto negativo en la satisfacción de los participantes en los ensayos de quimioprevención.
Los resultados sugieren la necesidad de abordar los eventos adversos y la duración del ensayo para mejorar la experiencia de los participantes.
Mejorar la satisfacción puede mejorar la acumulación de ensayos futuros, la retención, la adherencia y la diversidad en la investigación de prevención del cáncer.

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