Jove
Visualize
Contáctanos
JoVE
x logofacebook logolinkedin logoyoutube logo
ACERCA DE JoVE
Visión GeneralLiderazgoBlogCentro de Ayuda JoVE
AUTORES
Proceso de PublicaciónConsejo EditorialAlcance y PolíticasRevisión por ParesPreguntas FrecuentesEnviar
BIBLIOTECARIOS
TestimoniosSuscripcionesAccesoRecursosConsejo Asesor de BibliotecasPreguntas Frecuentes
INVESTIGACIÓN
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchivo
EDUCACIÓN
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualCentro de Recursos para ProfesoresSitio de Profesores
Términos y Condiciones de Uso
Política de Privacidad
Políticas

Videos de Conceptos Relacionados

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

2.3K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.3K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

12.4K
Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
12.4K
Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

Role Of Notch Signalling In Intestinal Stem Cell Renewal

2.2K
Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
2.2K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.2K
T Cell Types and Functions01:24

T Cell Types and Functions

1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K

También podría leer

Artículos Relacionados

Artículos vinculados a este trabajo por autores compartidos, revista y gráfico de citas.

Ordenar por
Same author

Serum DSDNA is Associated With Psoriasis.

Experimental dermatology·2026
Same author

Systemic Proteomic Alterations and Predictive Biomarkers of Paroxetine Response in Refractory Rosacea: A Secondary Analysis of a Randomized Clinical Trial.

JAMA dermatology·2026
Same author

Regulation of exosomal miR-513a and miR-149 expression by APE1 in PD-L1 and TCR immune regulation pathways to promote immune evasion in osteosarcoma.

Cancer genetics·2026
Same author

Surfactant Protein B Precursor Inhibit the Progression of Resectable Non-small Cell Lung Cancer by Suppressing eIF4F-mediated Immune Evasion and Cancer Stemness.

International journal of biological sciences·2026
Same author

Tranexamic acid protects human dermal fibroblasts from D-galactose-induced senescence via the GPR30/MAPK pathway.

Annals of medicine·2026
Same author

Efficacy and safety of combining microneedling with oral doxycycline for the treatment of rosacea: a retrospective comparative cohort study.

The Journal of dermatological treatment·2026

Video Experimental Relacionado

Updated: Sep 9, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

541

PI3 como un gen central común que vincula la dermatitis atópica y la colitis ulcerosa a través de mecanismos de

Dan Jian1, Jian Chen1, Jinping Yuan1

  • 1Department of Dermatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150000, People's Republic of China.

Journal of inflammation research
|September 3, 2025
PubMed
Resumen

Este estudio identifica el PI3 como un biomarcador potencial que relaciona la dermatitis atópica (DA) y la colitis ulcerosa (UC). Las vías compartidas de reclutamiento de células inmunes destacan CCR1 como un posible objetivo terapéutico para ambas afecciones inflamatorias.

Palabras clave:
Los biomarcadoresreclutamiento inmuneAprendizaje automáticoNeutrófilossecuenciación de ARN de una sola célula

Más Videos Relacionados

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

1.9K
Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment
12:34

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

898

Videos de Experimentos Relacionados

Last Updated: Sep 9, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

541
Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies
09:08

Investigating Target Gene Function in a CD40 Agonistic Antibody-induced Colitis Model using CRISPR/Cas9-based Technologies

Published on: June 2, 2021

1.9K
Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment
12:34

Author Spotlight: Exploring ShiDuGao's Multi-Target Approach in Anus Eczema Treatment

Published on: January 12, 2024

898

Área de la Ciencia:

  • Inmunología
  • La genética
  • Dermatología
  • Gastroenterología

Sus antecedentes:

  • La dermatitis atópica (AD) y la colitis ulcerosa (UC) son afecciones inflamatorias prevalentes con una patogénesis compartida poco clara.
  • La evidencia creciente sugiere un vínculo potencial entre la enfermedad de Alzheimer y la UC, lo que requiere una investigación sobre los mecanismos subyacentes comunes.
  • Comprender las características inmunológicas compartidas es crucial para desarrollar terapias efectivas y dirigidas para ambas enfermedades.

Objetivo del estudio:

  • Identificar los genes centrales y las vías inmunológicas clave comunes tanto a la dermatitis atópica como a la colitis ulcerosa.
  • Explorar la patogénesis compartida que subyace a la conexión entre la EA y la UC.
  • Identificar posibles biomarcadores de diagnóstico y objetivos terapéuticos para ambas afecciones.

Principales métodos:

  • Se utilizaron conjuntos de datos GEO (GSE121212, GSE75214) para identificar genes expresados diferencialmente (DEG) utilizando DESeq2 y limma.
  • Se realizó un análisis ponderado de la red de coexpresión génica (WGCNA) y un análisis de la red de interacción proteína-proteína (PPI) para encontrar genes comunes.
  • Empleó algoritmos de aprendizaje automático y secuenciación de ARN de una sola célula para identificar y validar genes hub y sus patrones de expresión.

Principales resultados:

  • Se identificaron siete genes candidatos comunes (CXCL1, CCL20, CXCL2, ZC3H12A, PI3, CXCL3, LCN2) asociados con la infiltración de células inmunes tanto en la EA como en la UC.
  • PI3 surgió como un gen hub significativo con un alto potencial de diagnóstico (AUC > 0,95) en tres modelos de aprendizaje automático.
  • La secuenciación de ARN unicelular confirmó una alta expresión de PI3 en queratinocitos de AD y células epiteliales intestinales de UC, correlacionándose con las quimiocinas involucradas en el reclutamiento de células inmunes.

Conclusiones:

  • Se descubrieron mecanismos de reclutamiento de células inmunes compartidas, particularmente involucrando a los macrófagos M1, las células T CD4 y los neutrófilos, en la EA y la UC.
  • Se identificó a PI3 como un potencial biomarcador común tanto para la dermatitis atópica como para la colitis ulcerosa.
  • Sugiere CCR1 como un objetivo terapéutico potencial debido a su papel en las vías inflamatorias compartidas.