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Nutrientes como moduladores epigenéticos en la enfermedad hepática esteatótica asociada a la disfunción metabólica
Santiago Rodriguez1,2, Maria Luiza Fernandes Dahlem3, Carina Rossoni4
1Directorate of Postgraduate Studies in Health Sciences, Universidad de las Américas, Quito 170521, Ecuador.
World journal of hepatology
|September 3, 2025
Resumen
La enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD) es común e influenciada por la epigenética. La dieta afecta al MASLD a través de cambios epigenéticos, destacando los micronutrientes para la prevención y el tratamiento.
Área de la Ciencia:
- Hepatología
- La epigenética
- Ciencias de la nutrición
Sus antecedentes:
- La enfermedad hepática estatotica asociada a la disfunción metabólica (MASLD, por sus siglas en inglés) es la enfermedad hepática crónica más prevalente a nivel mundial.
- El impacto de MASLD se extiende más allá de la epidemiología, causando cargas significativas para el paciente y la atención médica debido a complicaciones hepáticas y extrahepáticas.
- La regulación epigenética, incluida la metilación del ADN y la modificación de las histonas, se reconoce cada vez más como crucial en el desarrollo y la progresión de MASLD.
Objetivo del estudio:
- Explorar el papel de la dieta y la epigenética en la patogénesis de la enfermedad.
- Revisar la importancia de los micronutrientes específicos en la prevención o el tratamiento de la enfermedad.
- Proporcionar una visión de la naturaleza multifacética del MASLD.
Principales métodos:
- Revisión de la literatura centrada en los mecanismos epigenéticos en el MASLD.
- Análisis del impacto de la dieta occidental en la modulación epigenética.
- Identificación de los micronutrientes clave implicados en el MASLD.
Principales resultados:
- Los mecanismos epigenéticos como la metilación del ADN y la modificación de las histonas son fundamentales para el MASLD.
- La dieta, especialmente la dieta occidental, influye en la patogénesis de MASLD a través de las vías epigenéticas.
- Los micronutrientes juegan un papel importante en la prevención y el tratamiento de la enfermedad.
Conclusiones:
- La comprensión de MASLD requiere considerar su compleja interacción con la dieta y la epigenética.
- Las intervenciones guiadas por micronutrientes son prometedoras para el manejo de MASLD.
- La investigación adicional sobre las interacciones dieta-epigenéticas es esencial para el manejo de MASLD.
Palabras clave:
La epigenéticaEsteatosis hepáticaEnfermedad hepática esteatótica asociada a la disfunción metabólicaLa nutrigenéticaLa nutriciónMás Videos Relacionados
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