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Updated: Sep 9, 2025

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PRAME Expresión en el caso de nevíos melanocíticos recurrentes/persistentes

Alison H Kucharik1, Helana Ghali2, Doniya Milani1,3

  • 1Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, FL.

The American Journal of dermatopathology
|September 3, 2025
PubMed
Resumen
Este resumen es generado por máquina.

La inmunohistoquímica PRAME es útil para el diagnóstico de nevos melanocíticos recurrentes. Esta mancha ayuda a diferenciar los nevos benignos del melanoma, mejorando la confianza en el diagnóstico y reduciendo potencialmente los procedimientos innecesarios.

Palabras clave:
El PRAMEnevus recurrente

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Área de la Ciencia:

  • Dermatopatología
  • Inmunohistoquímica
  • En el campo de la oncología

Sus antecedentes:

  • Los nevos melanocíticos recurrentes pueden presentar características atípicas, lo que complica el diagnóstico, especialmente sin información previa de la biopsia.
  • La tinción de antígeno expresado preferencialmente en el melanoma (PRAME) se utiliza para el diagnóstico del melanoma, pero su papel en los nevos recurrentes no está claro.

Objetivo del estudio:

  • Evaluar la utilidad de la inmunohistoquímica PRAME para distinguir los nevos melanocíticos benignos recurrentes del melanoma.
  • Para evaluar la consistencia de la expresión PRAME entre el nevi original y el recurrente.

Principales métodos:

  • Se analizó la expresión de PRAME en nevos melanocíticos originales y recurrentes emparejados de 22 pacientes.
  • Se evaluó la inmunohistoquímica PRAME utilizando la intensidad de tinción, el porcentaje de melanocitos positivos y una puntuación compuesta.

Principales resultados:

  • Los patrones de expresión de PRAME fueron consistentes entre el nevi original y el recurrente.
  • Todos los casos analizados, tanto originales como recurrentes, mostraron puntuaciones compuestas negativas para la tinción PRAME.

Conclusiones:

  • La inmunohistoquímica de PRAME demuestra su utilidad para diferenciar los nevos recurrentes benignos de los melanoma.
  • Las puntuaciones compuestas PRAME consistentemente negativas en nevosis recurrentes aumentan la confianza en el diagnóstico y pueden ayudar a evitar procedimientos innecesarios.