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PRAME Expresión en el caso de nevíos melanocíticos recurrentes/persistentes
Alison H Kucharik1, Helana Ghali2, Doniya Milani1,3
1Department of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, FL.
The American Journal of dermatopathology
|September 3, 2025
Resumen
La inmunohistoquímica PRAME es útil para el diagnóstico de nevos melanocíticos recurrentes. Esta mancha ayuda a diferenciar los nevos benignos del melanoma, mejorando la confianza en el diagnóstico y reduciendo potencialmente los procedimientos innecesarios.
Área de la Ciencia:
- Dermatopatología
- Inmunohistoquímica
- En el campo de la oncología
Sus antecedentes:
- Los nevos melanocíticos recurrentes pueden presentar características atípicas, lo que complica el diagnóstico, especialmente sin información previa de la biopsia.
- La tinción de antígeno expresado preferencialmente en el melanoma (PRAME) se utiliza para el diagnóstico del melanoma, pero su papel en los nevos recurrentes no está claro.
Objetivo del estudio:
- Evaluar la utilidad de la inmunohistoquímica PRAME para distinguir los nevos melanocíticos benignos recurrentes del melanoma.
- Para evaluar la consistencia de la expresión PRAME entre el nevi original y el recurrente.
Principales métodos:
- Se analizó la expresión de PRAME en nevos melanocíticos originales y recurrentes emparejados de 22 pacientes.
- Se evaluó la inmunohistoquímica PRAME utilizando la intensidad de tinción, el porcentaje de melanocitos positivos y una puntuación compuesta.
Principales resultados:
- Los patrones de expresión de PRAME fueron consistentes entre el nevi original y el recurrente.
- Todos los casos analizados, tanto originales como recurrentes, mostraron puntuaciones compuestas negativas para la tinción PRAME.
Conclusiones:
- La inmunohistoquímica de PRAME demuestra su utilidad para diferenciar los nevos recurrentes benignos de los melanoma.
- Las puntuaciones compuestas PRAME consistentemente negativas en nevosis recurrentes aumentan la confianza en el diagnóstico y pueden ayudar a evitar procedimientos innecesarios.
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