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Desvelando el papel oncogénico y el valor pronóstico de ACTL6A en el cáncer: una revisión sistemática y un

Soumya Patil¹, Raushan Kumar Chaudhary², Prakash Patil³

¹Department of Pharmacy Practice, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), India.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

|September 3, 2025

Resumen

La proteína 6A similar a la actina (ACTL6A) impulsa la progresión del cáncer y los malos resultados. La sobreexpresión de ACTL6A está relacionada con una supervivencia reducida, tumores más grandes y grados más altos, lo que indica su potencial como marcador pronóstico.

Área de la Ciencia:

En el campo de la oncología
Biología molecular
La genética

Sus antecedentes:

La proteína 6A similar a la actina (ACTL6A) es una subunidad del complejo SWI/SNF implicado en el cáncer.
Su potencial oncogénico requiere una evaluación exhaustiva de su papel en la tumorigénesis y los resultados clínicos.

Objetivo del estudio:

Revisar y metaanalizar sistemáticamente el papel de ACTL6A en la fisiopatología del cáncer.
Evaluar el significado pronóstico de ACTL6A en cánceres humanos.

Principales métodos:

Búsqueda sistemática de la literatura de PubMed, Scopus y Web of Science hasta el 31 de diciembre de 2024.
Incluir los estudios sobre ACTL6A en el cáncer y los que informan de los ratios de riesgo para la expresión de ACTL6A.
Metaanálisis de seis estudios (n=863) para el pronóstico significativo.

Principales resultados:

Se revisaron 39 estudios, destacando el papel de ACTL6A en la tumorigénesis, la invasión y la metástasis a través de las vías de señalización clave (HIPPO-YAP, PI3K/AKT, NOTCH, Wnt/β-catenina).
La sobreexpresión de ACTL6A se correlacionó significativamente con una baja supervivencia global (p=0,001).
La sobreexpresión también se asoció con un mayor tamaño tumoral (p<0,01) y mayor grado tumoral (p=0,002).

Conclusiones:

ACTL6A actúa como un factor oncogénico crítico, promoviendo la progresión del cáncer y los resultados clínicos adversos.
ACTL6A demuestra potencial como marcador pronóstico en oncología.
Las estrategias terapéuticas dirigidas contra ACTL6A pueden ser beneficiosas.

Palabras clave:

Proteína similar a la actina 6A El cáncer Meta-análisis La supervivencia El examen sistemático

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