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Personalidad y envejecimiento epigenético: un estudio multicohorte y multiclock
Yannick Stephan1, Angelina R Sutin2, Martina Luchetti2
1Euromov, University of Montpellier, France.
Psychoneuroendocrinology
|September 3, 2025
Resumen
Una mayor conciencia está relacionada con un envejecimiento biológico más lento, medido por relojes epigenéticos avanzados. Este rasgo de personalidad puede influir en la salud y la longevidad.
Área de la Ciencia:
- Gerontología
- Ciencias del comportamiento
- La epigenética
Sus antecedentes:
- Los relojes epigenéticos cuantifican el envejecimiento biológico y se correlacionan con resultados de salud como la mortalidad.
- Comprender los factores que influyen en el envejecimiento biológico es crucial para promover la salud.
Objetivo del estudio:
- Investigar la relación entre los rasgos de personalidad y el envejecimiento epigenético.
- Para determinar si ciertos rasgos de personalidad están asociados con un envejecimiento biológico más lento o más rápido.
Principales métodos:
- Metaanálisis de datos de más de 6000 participantes en tres grandes estudios longitudinales.
- Evaluación de los rasgos de personalidad, factores demográficos y múltiples generaciones de relojes epigenéticos (Hannum, Horvath, PhenoAge, GrimAge, DunedinPoAM38/DunedinPace).
Principales resultados:
- La conciencia mostró una asociación consistente con un envejecimiento epigenético más lento, particularmente para los relojes de segunda y tercera generación.
- Otros rasgos de personalidad no mostraron asociaciones consistentes con los relojes epigenéticos.
- La aceptabilidad se relacionó con un envejecimiento epigenético más lento en adultos mayores, pero no en adultos más jóvenes.
Conclusiones:
- La conciencia es un correlato significativo de personalidad del envejecimiento epigenético más lento, especialmente cuando se usan relojes epigenéticos basados en resultados de salud.
- La personalidad puede desempeñar un papel en la modulación de los procesos de envejecimiento biológico y potencialmente de la salud.
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