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Comparación de la preparación intestinal de bajo volumen con la de volumen intermedio y su impacto en el trabajo y la

Milou L M van Riswijk¹, Fleur A Indemans², Kimberly Hawinkels³

¹Gastroenterology and hepatology, Radboudumc Afdeling Maag- Darm- en Leverziekten, Nijmegen, Netherlands.

|September 3, 2025

Resumen

La preparación intestinal de bajo volumen (1L PEG+Asc) es tan eficaz como la de alto volumen (2L PEG+Asc) para la colonoscopia. Los pacientes prefieren el volumen más bajo, mostrando una mayor voluntad de repetir el procedimiento.

Área de la Ciencia:

Gastroenterología
Ensayos clínicos
Resultados en pacientes

Sus antecedentes:

La preparación del intestino es crucial para la colonoscopia, pero a menudo es mal tolerada por los pacientes.
Los laxantes de bajo volumen pueden mejorar la tolerabilidad, pero su efecto en los resultados informados por los pacientes necesita más investigación.

Objetivo del estudio:

Comparar la eficacia y los resultados informados por los pacientes de la preparación intestinal de bajo volumen (1L PEG+Asc) frente a la de volumen intermedio (2L PEG+Asc) para la colonoscopia.
Evaluar si 1 L de PEG+Asc no es inferior a 2 L de PEG+Asc en cuanto a la limpieza intestinal adecuada.

Principales métodos:

Se realizó un ensayo aleatorizado abierto de no inferioridad en cuatro hospitales holandeses.
Los pacientes recibieron 2 L de PEG+Asc o 1 L de PEG+Asc con sulfato de sodio.
Los cuestionarios validados evaluaron la productividad, la tolerabilidad y la calidad de vida relacionada con la salud (HRQoL) antes y después de la preparación.

Principales resultados:

1L de PEG+Asc no fue inferior a 2L de PEG+Asc, con tasas de limpieza adecuadas del 96,1% frente al 96,4%.
Significativamente más pacientes en el grupo de 1L PEG+Asc estaban dispuestos a repetir el tratamiento (59,9% frente a 48,3%).
La tolerabilidad fue el factor más influyente para la voluntad de repetición; no se observaron diferencias significativas en la CQR, el absentismo o la productividad laboral.

Conclusiones:

La preparación intestinal de bajo volumen (1L PEG+Asc) es una alternativa viable a la preparación de volumen intermedio (2L PEG+Asc), que demuestra su eficacia limpiadora.
La tolerancia mejorada de los preparados de bajo volumen aumenta la voluntad del paciente de repetir, lo que potencialmente reduce las barreras a la colonoscopia.
La tolerabilidad es un factor clave que influye en el cumplimiento del paciente y en las tasas de repetición de la colonoscopia.

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