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Seguridad y eficacia del precondicionamiento isquémico remoto en la enfermedad renal diabética: un protocolo de
Lanjing Wang1, Linpei Jia2, Shuangfeng Huang1
1Department of Neurology, Xuanwu Hospital Capital Medical University, Beijing, China.
BMJ open
|September 3, 2025
Resumen
El precondicionamiento isquémico remoto (PIR) puede retrasar la insuficiencia renal en pacientes con enfermedad renal diabética (ERD). Este ensayo piloto investiga el PIR
Área de la Ciencia:
- Nefrología
- Medicina cardiovascular
- Fisiología isquémica
Sus antecedentes:
- La enfermedad renal diabética (ERD) es una de las principales causas de enfermedad renal terminal.
- El acondicionamiento isquémico remoto (RIP) es una intervención protectora contra la lesión isquémica.
- El potencial del PIR para mitigar la progresión de la DKD sigue siendo objeto de investigación.
Objetivo del estudio:
- Evaluar la eficacia del RIP en la disminución de la progresión de la insuficiencia renal en pacientes con DKD.
- Evaluar el impacto del PIR en los biomarcadores de DKD y los resultados cardiovasculares.
- Determinar la seguridad y tolerabilidad del PIR en esta población de pacientes.
Principales métodos:
- Un ensayo piloto, aleatorizado, de brazo paralelo, controlado por simulación en el que participaron 60 participantes con DKD (estadios 3-4 de CKD).
- Los participantes recibieron diariamente el PIR o el PIR simulado durante 3 meses, seguido de un seguimiento de 6 meses.
- Resultados primarios: incidencia de enfermedad renal terminal; resultados secundarios: cambios en los biomarcadores, eventos cardiovasculares y eventos adversos.
Principales resultados:
- Esta sección no es aplicable ya que el resumen describe un estudio en curso y no presenta resultados.
Conclusiones:
- Este estudio piloto tiene por objeto proporcionar datos preliminares sobre la eficacia y la seguridad del PIR para el tratamiento de la enfermedad renal diabética.
- Los hallazgos servirán de base para el diseño de ensayos más amplios que investiguen el PIR como estrategia terapéutica para la DKD.
- El estudio contribuirá a comprender el papel del RIP en la prevención de la insuficiencia renal y las complicaciones cardiovasculares en pacientes con DKD.
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