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Variación estacional en la deshidratación inducida por diuréticos utilizando informes espontáneos de eventos adversos
Satoshi Nakao1,2, Mika Maezawa1, Kohei Shiota1
1Laboratory of Drug Informatics, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
Biological & pharmaceutical bulletin
|September 3, 2025
Resumen
La deshidratación inducida por diuréticos (DID) es común en invierno y verano. Los proveedores de atención médica deben aconsejar a los pacientes que toman diuréticos que mantengan una ingesta adecuada de agua durante todo el año, especialmente durante los meses más fríos.
Área de la Ciencia:
- Farmacovigilancia de las sustancias
- Medicina Clínica
- Salud pública
Sus antecedentes:
- Los diuréticos son tratamientos esenciales para la insuficiencia cardíaca y la hipertensión.
- Comprender los eventos adversos de los medicamentos como la deshidratación inducida por diuréticos (DID) es crucial para la seguridad del paciente.
Objetivo del estudio:
- Analizar las variaciones estacionales en la deshidratación inducida por diuréticos (DID) utilizando datos del mundo real.
- Identificar los períodos de pico de notificación para el DID para informar la práctica clínica.
Principales métodos:
- Análisis retrospectivo de la base de datos del Informe de acontecimientos adversos relacionados con medicamentos de Japón (JADER).
- Relaciones de notificación mensual (RR) examinadas de DID para 11 diuréticos desde enero de 2003 hasta diciembre de 2023.
Principales resultados:
- La deshidratación inducida por diuréticos (DID) fue reportada con mayor frecuencia en enero, seguida de agosto.
- Los informes de DID fueron notablemente comunes durante los meses de invierno (diciembre, enero y febrero).
Conclusiones:
- La deshidratación inducida por diuréticos (DID) ocurre tanto en invierno como en verano.
- Los proveedores de atención médica deben recomendar una ingesta adecuada de agua para los pacientes que toman diuréticos durante todo el año, incluido el invierno, para evitar la deshidratación.
Palabras clave:
Base de datos japonesa de informes de efectos adversos de las drogasacontecimiento adversoDeshidratacióndiuréticoVariación estacionalMás Videos Relacionados
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