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El impacto de la estadificación del síndrome cardiovascular-renal-metabólico en el riesgo de depresión: un estudio
Bowen Zha1, Angshu Cai1, Hongrui Yu2
1National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China.
Heart, lung & circulation
|September 3, 2025
Resumen
El riesgo de depresión aumenta con la gravedad del síndrome cardiovascular-renal-metabólico (SCM). Esta asociación es más fuerte en mujeres, adultos mayores, estadounidenses mexicanos y aquellos con menos educación, lo que indica una necesidad de atención integrada.
Área de la Ciencia:
- Cardiología
- Nefrología
- Salud metabólica
- La psiquiatría
- Salud pública
Sus antecedentes:
- El síndrome cardiovascular-renal-metabólico (CKM) integra la enfermedad cardiovascular, la enfermedad renal crónica y los trastornos metabólicos.
- No se comprende bien la relación entre las etapas del síndrome de CKM y el riesgo de depresión.
- Este estudio investiga la asociación entre la gravedad del síndrome de CKM y la depresión.
Objetivo del estudio:
- Determinar si el aumento de las etapas del síndrome de CKM está asociado con una mayor prevalencia de depresión.
- Identificar grupos sociodemográficos específicos con mayor riesgo de depresión dentro del espectro del síndrome CKM.
Principales métodos:
- Análisis de 4.097 adultos de la Encuesta Nacional de Examen de Salud y Nutrición (2005-2020).
- Depresión evaluada mediante el Cuestionario de Salud del Paciente-9 (PHQ-9).
- Estadios de CKM clasificados según las directrices de la Asociación Americana del Corazón de 2023; regresión logística multivariable utilizada para el análisis.
Principales resultados:
- El riesgo de depresión aumentó progresivamente con la etapa del síndrome de CKM, especialmente en la Etapa 4 (OR 1.112).
- Se observaron asociaciones significativas en las etapas 2 y 3.
- Las asociaciones más fuertes se encuentran en mujeres, adultos mayores, estadounidenses mexicanos e individuos con baja educación.
Conclusiones:
- El avance en la etapa del síndrome de CKM está significativamente relacionado con un mayor riesgo de depresión.
- Los grupos sociodemográficos vulnerables experimentan un riesgo desproporcionadamente mayor.
- Las estrategias integradas de salud mental son cruciales para el manejo integral del síndrome de CKM.
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