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Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Mitochondria01:37

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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Reloj de envejecimiento basado en el metabolismo

A Ibáñez de Opakua1, R Conde2, A de Diego2

  • 1ATLAS Molecular Pharma, Parque Tecnológico de Bizkaia, Ed. 800, 48160, Derio, Spain.

npj metabolic health and disease
|September 3, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los relojes moleculares de envejecimiento, como los relojes metabólicos basados en RMN, predicen los resultados de salud mejor que la edad cronológica. Un nuevo enfoque mejora la precisión y la interpretabilidad para la detección acelerada del envejecimiento.

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Área de la Ciencia:

  • Los biomarcadores y la investigación en el ámbito sanitario
  • Metabolomía y Ciencia del Envejecimiento

Sus antecedentes:

  • Los relojes moleculares de envejecimiento estiman la edad biológica, superando la edad cronológica en la predicción de resultados de salud.
  • Los relojes epigenéticos, transcriptómicos, proteómicos y metabólicos son los tipos clave.
  • Los relojes metabólicos basados en RMN ofrecen una evaluación de la salud metabólica no invasiva y de alto rendimiento.

Objetivo del estudio:

  • Resumir los modelos de reloj de envejecimiento metabólico basados en RMN existentes.
  • Introducir un nuevo enfoque basado en RMN para el desarrollo de relojes de envejecimiento.
  • Mejorar la precisión predictiva y la interpretabilidad clínica de la estimación de la edad biológica.

Principales métodos:

  • Revisión y síntesis de la literatura actual sobre el reloj metabólico basado en RMN.
  • Desarrollo de un nuevo modelo computacional que integre datos metabolómicos.
  • Validación del modelo para predecir el envejecimiento acelerado y el riesgo de enfermedad.

Principales resultados:

  • Se identificaron firmas metabólicas clave basadas en RMN asociadas con el envejecimiento biológico.
  • El nuevo enfoque demuestra una alta precisión predictiva para la edad biológica.
  • El modelo identifica con éxito las distorsiones metabólicas específicas de la enfermedad.

Conclusiones:

  • Los relojes metabólicos basados en RMN son herramientas valiosas para evaluar la salud metabólica y la edad biológica.
  • El enfoque presentado aumenta la utilidad clínica de los relojes de envejecimiento.
  • Este método apoya la estratificación del riesgo y la detección temprana del envejecimiento acelerado.