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Índice de inflamación inmunológica sistémica y proporción de neutrófilos a linfocitos: asociación en forma de U con
Qinglong Yang1, Haolin Chen2, Hanyuan Lin1,3
1Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Lower urinary tract symptoms
|September 3, 2025
Resumen
El índice de inflamación inmunológica sistémica (SII) y la relación entre neutrófilos y linfocitos (NLR) pueden indicar un riesgo de vejiga hiperactiva (OAB). Se observaron asociaciones en forma de U, con niveles más altos de SII y NLR vinculados a una mayor prevalencia de OAB.
Área de la Ciencia:
- Urología
- Inmunología
- Salud pública
Sus antecedentes:
- La vejiga hiperactiva (OAB) es una afección común que afecta la calidad de vida.
- La inflamación y las respuestas inmunes se reconocen cada vez más en diversas enfermedades crónicas.
Objetivo del estudio:
- Investigar la asociación entre el índice de inflamación inmunológica sistémica (SII) y la proporción de neutrófilos y linfocitos (NLR) con la prevalencia de la vejiga hiperactiva (OAB).
Principales métodos:
- Estudio transversal de 22.343 adultos estadounidenses (≥ 20 años) utilizando datos de NHANES (2005-2018).
- Se emplearon análisis de regresión logística multivariada y de spline cúbico restringido (RCS).
- Se realizaron análisis de subgrupos y de sensibilidad para validar los hallazgos.
Principales resultados:
- El análisis de RCS reveló relaciones en forma de U tanto para SII como para NLR con OAB.
- Los niveles elevados de SII (> 6,13) y NLR (> 0,65) estuvieron asociados positivamente con la prevalencia de OAB (ORs 1,32 y 1,40, respectivamente).
- El SII inferior (≤6,13) mostró una asociación negativa con el OAB (OR 0,83).
Conclusiones:
- SII y NLR muestran potencial como biomarcadores predictivos para el riesgo de vejiga hiperactiva.
- Estos marcadores inflamatorios pueden ayudar a identificar a las personas con mayor riesgo de OAB.
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