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A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
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[Efectos transversal de la intervención farmacológica: farmacología indirecta]
Jia-Bo Wang1, Hai-Yu Xu2, Hong-Jun Yang3
1School of Traditional Chinese Medicine, Capital Medical University Beijing 100069, China.
Resumen
Este estudio introduce la farmacología indirecta, centrándose en cómo las sustancias intermedias median los efectos del fármaco en los órganos. Este enfoque holístico ofrece nuevas estrategias para enfermedades complejas mediante la comprensión de la comunicación entre órganos.
Área de la Ciencia:
- Biología de sistemas
- Farmacología
- La medicina integrada
Sus antecedentes:
- Las enfermedades complejas implican interacciones intrincadas entre múltiples órganos, tejidos y células.
- La farmacología convencional, centrada en objetivos aislados, lucha con enfermedades multifacéticas.
- Se reconoce cada vez más que la comunicación entre órganos es crucial en la progresión de la enfermedad y la intervención farmacológica.
Objetivo del estudio:
- Proponer la farmacología indirecta como un nuevo marco para la comprensión y el tratamiento de enfermedades complejas.
- Explorar el potencial de las estrategias de regulación multiorgánica y holística.
- Aprovechar las ideas de la medicina tradicional china (MTC) sobre la comunicación entre los órganos.
Principales métodos:
- Revisión de la literatura existente sobre la biología de los sistemas y el diálogo cruzado entre órganos.
- Análisis de los principios de la medicina tradicional china (MTC) relacionados con el tratamiento holístico y sistémico.
- Desarrollo conceptual de la farmacología indirecta mediada por sustancias intermedias.
Principales resultados:
- Las enfermedades complejas requieren un enfoque sistémico más allá de los objetivos moleculares aislados.
- Las vías de comunicación entre órganos ofrecen nuevos objetivos terapéuticos.
- La farmacología indirecta proporciona una nueva lente para el descubrimiento de fármacos y las estrategias de intervención.
Conclusiones:
- Un enfoque holístico y multiorgánico es esencial para hacer frente a enfermedades complejas.
- La farmacología indirecta, mediada por sustancias intermedias, representa una extensión significativa de la farmacología clásica.
- Este marco abre nuevas vías para el desarrollo de estrategias terapéuticas innovadoras entre órganos.
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