Video Experimental Relacionado

Updated: May 9, 2026

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy

Assessing Collagen and Elastin Pressure-dependent Microarchitectures in Live, Human Resistance Arteries by Label-free Fluorescence Microscopy

Published on: April 9, 2018

Evaluación cuantitativa tridimensional de la remodelación de la fibra aórtica inducida por la hipertensión basada en

Nannan Wang^1,2, Rongli Zhang^1,2,3, Anni Zhao^1,2

¹Research Center for Biomedical Optics and Molecular Imaging, Shenzhen Key Laboratory for Molecular Imaging, Guangdong Provincial Key Laboratory of Biomedical Optical Imaging Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China.

Royal Society open science

|September 4, 2025

Resumen

Este estudio revela cómo la hipertensión altera la estructura de las fibras aórticas a través de diferentes edades utilizando imágenes avanzadas. Los hallazgos iluminan los cambios a nivel micro en el envejecimiento aórtico y la hipertensión, ayudando a la investigación de enfermedades cardiovasculares.

Área de la Ciencia:

Ciencias cardiovasculares
Ingeniería biomédica
Investigación sobre el envejecimiento

Sus antecedentes:

La hipertensión es una de las principales causas de enfermedades cardiovasculares a nivel mundial.
La remodelación de la fibra aórtica es crucial en el desarrollo de la hipertensión y está relacionada con el envejecimiento.
Los cambios de micronivel en la estructura aórtica durante la hipertensión siguen siendo poco conocidos.

Objetivo del estudio:

Evaluar cuantitativamente la remodelación microestructural de las fibras aórticas inducida por la hipertensión.
Para investigar los cambios relacionados con la edad en la estructura de la fibra aórtica en condiciones hipertensivas.
Para explorar las variaciones en la respuesta de los segmentos aórticos a la hipertensión.

Principales métodos:

Se utilizó microscopía multifotónica sin etiqueta (MPM) para obtener imágenes de las fibras de colágeno y elastina aórticas.
Se empleó un algoritmo tridimensional (3D) de matriz de coincidencia de nivel gris (GLCM) para el análisis de la textura.
Se examinaron muestras de ratas hipertensas espontáneas y controles de Wistar-Kyoto en tres etapas de edad y dos segmentos aórticos.

Principales resultados:

Se identificaron características significativas de la textura 3D GLCM correlacionadas con la hipertensión y la hipertensión relacionada con la edad.
Remodelación aórtica inducida por hipertensión cuantificada y envejecimiento aórtico acelerado a nivel microestructural.
Se han demostrado respuestas heterogéneas de los segmentos de la aorta abdominal y torácica a la hipertensión.

Conclusiones:

El enfoque combinado de MPM y 3D GLCM proporciona nuevos conocimientos sobre los cambios microstructurales aórticos inducidos por la hipertensión.
Los hallazgos aclaran los mecanismos de la hipertensión relacionada con la edad y la remodelación aórtica.
Esta investigación contribuye a comprender la patogénesis de las enfermedades cardiovasculares y los posibles objetivos terapéuticos.

Palabras clave:

Matriz de co-ocurrencia en el nivel gris 3D remodelación de las fibras aórticas Evaluación entre edades hipertensión microscopía multifotónica

Más Videos Relacionados

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Multimodal Study of Murine Cardiovascular Remodeling: Four-Dimensional Ultrasound and Mass Spectrometry Imaging

Published on: January 10, 2025

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

Videos de Conceptos Relacionados

Assessment of blood pressure in brachial artery(one-step method)

Assessment of blood pressure in brachial artery(one-step method)

This procedural guide systematically measures blood pressure using an oscillometric digital sphygmomanometer, emphasizing accuracy, patient safety, and comfort.
Prepare for the Procedure:

Assessment of blood pressure in brachial artery(two-step method)

Assessment of blood pressure in brachial artery(two-step method)

Measuring blood pressure is a fundamental skill in healthcare that aids in diagnosing and monitoring hypertension and other cardiovascular conditions. An aneroid sphygmomanometer, commonly used in clinical settings, offers a manual and precise method for blood pressure measurement. The technique for using this instrument involves specific steps that must be carefully executed to ensure accuracy. The following detailed description outlines a two-step technique for assessing blood pressure using...

Special considerations while measuring blood pressure

Special considerations while measuring blood pressure

When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.

Measurement of Blood Pressure

Measurement of Blood Pressure

Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a stethoscope.

Imaging Studies for Cardiovascular System IV: CMRI

Imaging Studies for Cardiovascular System IV: CMRI

Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...