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Updated: Sep 9, 2025
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Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
Published on: November 29, 2024
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La activación plaquetaria y la biosignatura plaquetaria están asociadas con el riesgo cardiovascular en pacientes con
Michael S Garshick1,2,3,4, Kamelia Drenkova2, Filipp Kazatsker2
1Department of Medicine, Center for the Prevention of Cardiovascular Disease, New York University School of Medicine. (M.S.G., J.S.B.).
Arteriosclerosis, thrombosis, and vascular biology
|September 4, 2025
Resumen
Las plaquetas son más activas en pacientes con psoriasis, mostrando una expresión génica alterada relacionada con la inflamación y la coagulación. Este perfil plaquetario predice un mayor riesgo de enfermedad cardiovascular, destacando un objetivo terapéutico potencial.
Área de la Ciencia:
- Investigación cardiovascular
- Dermatología
- Inmunología
- La genómica
Sus antecedentes:
- Los mecanismos de la aterosclerosis y la identificación del riesgo cardiovascular en la psoriasis siguen sin estar claros.
- El aumento de la actividad plaquetaria en la psoriasis contribuye a la disfunción vascular.
- La investigación del fenotipo plaquetario y el transcriptoma ofrece información sobre el riesgo cardiovascular relacionado con la psoriasis.
Objetivo del estudio:
- Para investigar el fenotipo plaquetario y el transcriptoma en pacientes con psoriasis.
- Para determinar la asociación entre los perfiles transcriptómicos de las plaquetas y el riesgo cardiovascular.
- Explorar los mecanismos impulsados por las plaquetas que contribuyen a la enfermedad cardiovascular en la psoriasis.
Principales métodos:
- Los pacientes con psoriasis y los controles se sometieron a estudios de agregación y activación plaquetaria.
- Se realizó la secuenciación del ARN plaquetario para generar una puntuación transcriptómica plaquetaria de la psoriasis.
- Se evaluó la correlación de la puntuación con la rigidez arterial, el calcio coronario y el infarto de miocardio incidente.
Principales resultados:
- Los pacientes con psoriasis presentaron una mayor agregación plaquetaria y un aumento de los agregados leucocitos, neutrófilos y linfocitos-plaquetas.
- La secuenciación del ARN plaquetario reveló patrones de expresión génica distintos en la psoriasis, asociados con las vías de inflamación y coagulación.
- La puntuación transcriptómica plaquetaria de la psoriasis se correlacionó con la rigidez arterial, el calcio coronario y predijo el infarto de miocardio en individuos de alto riesgo.
Conclusiones:
- El aumento de la agregación y activación plaquetaria en la psoriasis está relacionado con las vías proinflamatorias y proaterotrombóticas.
- El transcriptoma plaquetario en la psoriasis está asociado con un mayor riesgo cardiovascular.
- La participación de las plaquetas requiere una investigación adicional como un factor clave en la enfermedad cardiovascular asociada a la psoriasis.
Palabras clave:
La aspirina también.las plaquetas sanguíneasel endotelioinflamaciónEnfermedad de la pielMás Videos Relacionados
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