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Avances recientes de los luminógenos de emisión inducida por agregación en la enfermedad cardiovascular

Yue Lan¹, Sheng'e Su¹, Jiageng Cai²

¹The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, 100191, China.

Advanced healthcare materials

|September 4, 2025

Resumen

Los luminógenos de emisión inducida por agregación (AIEgens) son prometedores para el diagnóstico y tratamiento de la enfermedad cardiovascular aterosclerótica (ASCVD). Esta revisión destaca las propiedades y aplicaciones de AIEgen en la detección, la imagen y el tratamiento de ASCVD.

Área de la Ciencia:

* Nanotecnología y Ciencias de los Materiales
* Ingeniería biomédica
* Química medicinal

Sus antecedentes:

* La enfermedad cardiovascular aterosclerótica (ASCVD) es una de las principales causas de mortalidad en el mundo.
* El desarrollo de la placa implica la acumulación de lípidos en las paredes de las arterias, lo que lleva a complicaciones graves.
* Los nuevos agentes diagnósticos y terapéuticos son cruciales para el tratamiento de la EACV.

Objetivo del estudio:

* Revisar los avances recientes en los luminógenos de emisión inducida por agregación (AIEgens) para ASCVD.
* Explorar las propiedades de AIEgen y su diseño para el manejo de ASCVD.
* Para resumir las aplicaciones de AIEgen en la detección de biomarcadores de ASCVD, imágenes y tratamiento.

Principales métodos:

* Revisión sistemática de la literatura sobre la investigación del AIEgen en la EACV (los últimos cinco años).
* Análisis de las características del AIEgen: fluorescencia, fotostabilidad, biocompatibilidad.
* Evaluación de las aplicaciones de AIEgen en detección, imágenes y terapia.

Principales resultados:

* Los AIEgens exhiben fluorescencia mejorada en estados agregados, ideales para aplicaciones biomédicas.
* Los diseños personalizados de AIEgen facilitan la detección e imágenes efectivas de biomarcadores de ASCVD.
* Los AIEgen demuestran potencial en las estrategias terapéuticas para ASCVD.

Conclusiones:

* Los AIEgens representan una clase prometedora de materiales para el diagnóstico y tratamiento de la EACV.
* Se necesita más investigación para abordar los desafíos actuales y optimizar la utilidad de AIEgen.
* Las perspectivas futuras incluyen el desarrollo mejorado de AIEgen para la gestión integral de ASCVD.

Palabras clave:

luminógenos de emisión inducida por agregación Enfermedad cardiovascular aterosclerótica Detección de biomarcadores Diagnóstico y tratamiento

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