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La conexión entre el transportador de quercetina y la serotonina (SERT): ¿una nueva esperanza para el tratamiento de

Meesala Krishna Murthy¹

¹Department of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Punjab, 140401, India. krishnameesala6@gmail.com.

Psychopharmacology

|September 4, 2025

Resumen

La quercetina es prometedora para el tratamiento de la depresión mediante la modulación del transportador de serotonina (SERT) y la reducción de la inflamación. Si bien ofrecen efectos más rápidos que los ISRS, los desafíos de biodisponibilidad deben abordarse para su uso clínico.

Área de la Ciencia:

La neurociencia
Farmacología
La bioquímica

Sus antecedentes:

La fisiopatología del trastorno depresivo mayor (TDM) implica una compleja desregulación del sistema serotoninérgico, estrés oxidativo e inflamación.
Los inhibidores selectivos de la recaptación de serotonina (ISRS) inhiben principalmente el transportador de serotonina (SERT) con un retraso en el tiempo.
La quercetina, un flavonoide natural, interactúa con el SERT e influye en las vías celulares clave.

Objetivo del estudio:

Para explorar el potencial de la quercetina como agente antidepresivo.
Elucidar los mecanismos de acción de la quercetina sobre el transportador de serotonina (SERT) y las vías relacionadas.
Para comparar los efectos de la quercetina con los ISRS convencionales.

Principales métodos:

Revisión de las pruebas preclínicas y clínicas sobre los efectos de la quercetina en la SERT, la neuroinflamación, el estrés oxidativo, la neuroplasticidad y el eje intestino-cerebro.
Análisis de los efectos moduladores directos e indirectos de la quercetina en comparación con los mecanismos de los ISRS.
Identificación de vías como NF-kB, AMPK/SIRT-1 y Nrf2-ARE involucradas en la acción de la quercetina.

Principales resultados:

La quercetina exhibe efectos moduladores directos e indirectos sobre el SERT, distintos de la inhibición de los ISRS.
La quercetina reduce los marcadores oxidativos e inflamatorios a través de vías como el NF-kB, el AMPK/SIRT-1 y el Nrf2-ARE.
Los datos preclínicos sugieren que la quercetina puede ofrecer efectos antidepresivos más rápidos y extensos que los ISRS.
La quercetina influye positivamente en la neuroplasticidad y en el eje intestino-cerebro.

Conclusiones:

La quercetina presenta una estrategia terapéutica prometedora para el TDM, dirigida a múltiples aspectos de la fisiopatología de la depresión.
Se necesita más investigación para abordar la biodisponibilidad de la quercetina y optimizar las formulaciones para la traducción clínica.
Los ensayos futuros deben monitorear los marcadores inflamatorios y utilizar formulaciones de quercetina adaptadas para maximizar la eficacia.

Palabras clave:

Eje intestino-cerebro Trastorno depresivo mayor Las nanopartículas Neuroprotección Quercetina y sus derivados El transportador de la serotonina

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