Video Experimental Relacionado
Updated: Sep 9, 2025
06:29
Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
Published on: May 25, 2022
2.4K
Riesgo de comorbilidades oftalmológicas en pacientes con hidradenitis supurativa
Jason J Jo1, Hannah Verma2, Omar Alani2
1Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ocular immunology and inflammation
|September 4, 2025
Resumen
La hidradenitis supurativa (HS) está relacionada con un mayor riesgo de enfermedades oculares graves como úlceras corneales y escleritis. Sin embargo, los tratamientos biológicos pueden reducir el riesgo de conjuntivitis en pacientes con EH.
Área de la Ciencia:
- Oftalmología
- Dermatología
- Reumatología
- Epidemiología
Sus antecedentes:
- La hidradensitis supurativa (HS) es una enfermedad inflamatoria crónica de la piel.
- Las manifestaciones oculares de la esclerosis múltiple no están bien establecidas.
- Comprender la asociación entre la esclerosis múltiple y las enfermedades oculares es crucial para la atención integral del paciente.
Objetivo del estudio:
- Investigar la asociación entre la hidradenitis suppurativa (HS) y el riesgo de desarrollar enfermedades inflamatorias e infecciosas oculares.
- Analizar el impacto de los medicamentos biológicos en el riesgo de enfermedad ocular en pacientes con EH.
Principales métodos:
- Se realizó un estudio de cohorte emparejado utilizando la base de datos Global TriNetX.
- El estudio incluyó a 57.749 adultos con diagnóstico de HS y un grupo de control.
- Se calcularon los ratios de riesgo relativo (RR) para diversas afecciones oculares y se analizaron en función del estado del tratamiento biológico.
Principales resultados:
- Los adultos con HS mostraron un mayor riesgo de úlceras corneales (RR: 1,66), úlceras corneales marginales (RR: 2,82) y escleritis (RR: 1,89).
- Se observó una disminución del riesgo de conjuntivitis (RR: 0,75), conjuntivitis atópica aguda (RR: 0,78) y conjuntivitis mucopurulenta (RR: 0,71) en pacientes con EHS.
- El tratamiento con adalimumab o secukinumab se asoció con un riesgo reducido de conjuntivitis en pacientes con EH en comparación con aquellos que no recibieron medicamentos biológicos (RR: 0,62).
Conclusiones:
- Hidradenensitits suppurativa (HS) se asocia con un riesgo significativamente mayor de desarrollar úlceras corneales y escleritis.
- La terapia biológica en pacientes con EH puede ofrecer un efecto protector contra la conjuntivitis.
- Se necesitan más investigaciones para aclarar los mecanismos subyacentes a estas asociaciones y el papel de los productos biológicos en la salud ocular de los pacientes con EH.
Videos de Conceptos Relacionados
01:25Glaucoma: Overview
740
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
740
01:27Open Angle Glaucoma: Treatment
554
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
554
01:28Angle Closure Glaucoma: Treatment
665
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
665
01:26Sexually Transmitted Infections
410
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
410
01:24Nephrotic Syndrome I : Introduction
25
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
25
01:26Factors Affecting the Risk of Infection
12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K