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Variaciones hematológicas en niños con síndrome de Down

Golda Grinberg1, Gwen Sokoloff2, Beverly Hay2

  • 1Children's Medical Center, University of Texas Southwestern Medical Center, Dallas, TX.

Journal of pediatric hematology/oncology
|September 4, 2025
PubMed
Resumen
Este resumen es generado por máquina.

Los niños con síndrome de Down presentan rangos distintos de conteo sanguíneo completo (CBC), incluido un volumen corpuscular promedio más alto y un recuento de linfocitos más bajo. Estos hallazgos sugieren variaciones hematológicas benignas en la población de DS.

Palabras clave:
recuento sanguíneoSíndrome de DownLa hemoglobina tambiénEl linfocitovolumen corpuscular medio

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Área de la Ciencia:

  • Hematología pediátrica
  • Genética y trastornos genéticos
  • Patología clínica

Sus antecedentes:

  • Las anomalías hematológicas en niños con síndrome de Down (SD) están documentadas, pero carecen de conclusiones consistentes.
  • El establecimiento de rangos de referencia fiables para el hemograma completo (CBC) en DS es crucial para una evaluación clínica precisa.
  • Los estudios anteriores presentan datos contradictorios con respecto a los parámetros específicos del CBC en las poblaciones pediátricas de DS.

Objetivo del estudio:

  • Evaluar y definir rangos de hemograma completo (CBC) específicamente para niños diagnosticados con síndrome de Down (DS).
  • Proporcionar un recurso clínico mediante la presentación de valores medios de CBC estratificados por edad y sexo para pacientes pediátricos con DS.
  • Identificar y caracterizar las variaciones hematológicas comunes observadas en niños con síndrome de Down.

Principales métodos:

  • Análisis retrospectivo de una cohorte de una sola institución.
  • Evaluación del recuento sanguíneo completo (CBC) de pacientes pediátricos con síndrome de Down (SD).
  • Comparación de los parámetros CBC observados con los valores de referencia establecidos.

Principales resultados:

  • Los niños con síndrome de Down (SD) mostraron un mayor volumen corpuscular medio (MCV) en comparación con los valores de referencia.
  • Se observó constantemente un recuento absoluto de linfocitos más bajo en la cohorte pediátrica de DS.
  • Se observó una tendencia hacia valores más altos de hemoglobina (Hgb) en niños con DS.

Conclusiones:

  • Los hallazgos hematológicos identificados (elevación del MCV, reducción de linfocitos, tendencia al aumento de Hgb) parecen ser variaciones consistentes en niños con síndrome de Down (SD).
  • Se sugiere que estas variaciones son benignas y representan perfiles hematológicos característicos en la población de DS.
  • El estudio proporciona datos esenciales para la interpretación precisa de los resultados del CBC en las evaluaciones pediátricas de DS.