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Los modos de especificación del destino celular dan forma a la evolución del transcriptoma en la escisión espiral

Yan Liang1,2, Jingcheng Wei1, Yue Kang3

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El desarrollo temprano de los animales muestra una sorprendente plasticidad transcriptómica durante la escisión en espiral, a pesar de la morfología conservada. Esto sugiere una disociación evolutiva de la expresión génica y la forma en los anelidos.

Palabras clave:
Las anelidasTransición materna a cigóticaEstadio FilotípicoEscisión en espiralActivación del genoma cigótico

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Área de la Ciencia:

  • Biología del desarrollo
  • Biología evolutiva
  • La genómica

Sus antecedentes:

  • El desarrollo temprano de los animales exhibe características conservadas y plásticas en diferentes linajes.
  • Los espirales, incluidos los anelidos, comparten un programa de escisión en espiral conservado y linajes celulares.
  • Las razones de los patrones de desarrollo conservados versus plásticos siguen sin estar claras.

Objetivo del estudio:

  • Investigar la dinámica transcriptómica durante el desarrollo temprano en dos especies de anelidos con escisión en espiral.
  • Para comparar especies con diferentes modos de especificación de células progenitoras primarias.
  • Comprender la interacción entre la conservación morfológica y transcriptómica en la embriogénesis de los anelidos.

Principales métodos:

  • Análisis transcriptómico de alta resolución del curso temporal desde el ovocito hasta la gastrulación.
  • Análisis comparativo de los patrones de expresión génica en *Owenia fusiformis* y *Capitella teleta*.
  • Identificación de dominios de expresión génica conservados para los factores de transcripción ortólogos.

Principales resultados:

  • Se observaron diferencias significativas en la dinámica de transcripción durante la escisión en espiral entre las dos especies.
  • Los perfiles transcriptómicos convergieron hacia el final de la escisión y durante la gastrulación.
  • Se identificaron dominios de expresión génica conservados para factores clave de transcripción durante etapas posteriores.

Conclusiones:

  • El desarrollo temprano de los anelidos muestra plasticidad transcriptómica oculta durante la escisión espiral.
  • Los tiempos distintos de la especificación del organizador embrionario se correlacionan con la dinámica transcriptómica específica de la especie.
  • Una transición de desarrollo medio, caracterizada por la similitud transcriptómica, ocurre al final de la escisión y la gastrulación, lo que indica un desacoplamiento evolutivo de la morfología y la transcriptómica.